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货号： bs-2894R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2894R-Cy7
- 英文名称
- Anti-HDAC11/Cy7
- 中文名称
- Cy7标记的组蛋白去乙酰化酶11抗体
- 别 名
- HD 11; HD11; HDAC 11; Histone deacetylase 11; FLJ22237; HDA11_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Horse,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HDAC11
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Histone deacetylases (HDAC) are a family of 11 enzymes that are involved in the regulation of gene activation and silencing by regulating chromatin structure. HDAC11 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Deacetylation of histones is associated with the condensation of chromatin to a compact structure (heterochromatin) in which the genes are silenced. Each member of the HDAC family exhibits a different, individual substrate specificity and function in vivo.
HDACs are known to be associated with a number of well characterized cellular oncogenes and tumour- suppressor genes and inhibitors of HDACs induce growth arrest, differentiation or apoptosis of cancer cells in vitro and in vivo.
Function:
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Subunit:
Interacts with HDAC6.
Subcellular Location:
Nucleus. Note=Predominantly nuclear.
Tissue Specificity:
Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
Similarity:
Belongs to the histone deacetylase family.
Database links:Entrez Gene: 79885 Human
Entrez Gene: 232232 Mouse
Entrez Gene: 297453 Rat
Omim: 607226 Human
SwissProt: Q96DB2 Human
SwissProt: Q91WA3 Mouse
Unigene: 728246 Human
Unigene: 744132 Human
Unigene: 206218 Mouse
Unigene: 28065 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.