产品中心
当前位置：首页>产品中心Anti-Myogenin/Cy7
货号： bs-3550R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3550R-Cy7
- 英文名称
- Anti-Myogenin/Cy7
- 中文名称
- Cy7标记的肌细胞生成素抗体
- 别 名
- MYOG; bHLHc3; cb553; MYF 4; MYF4; Myf-4; MYOG; Myogenic factor 4; Myogenic factor 4 myogenin; MYOGENIN; Myogenin myogenin factor 4; OTTHUMP00000039094; Class C basic helix-loop-helix protein 3; MYOG_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 心血管 激酶和磷酸酶 结合蛋白 细胞表面分子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 25kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MYOG/Myogenin
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. It is a member of a large family of proteins related by sequence homology, the helix-loop-helix (HLH) proteins. It is essential for the development of functional skeletal muscle. [provided by RefSeq, Jul 2008]
Function:
Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Cooperates also with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Plays also a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts.
Subunit:
Homodimer and heterodimer with E12; heterodimerization enhances MYOG DNA-binding and transcriptional activities. Interacts with SMARCA4/BRG1/BAF190A. Interacts (via C-terminus region) with SSRP1 and SUPT16H; the interaction is indicative of an interaction with the FACT complex.
Subcellular Location:
Nucleus. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.
Post-translational modifications:
Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles.
Similarity:
Contains 1 bHLH (basic helix-loop-helix) domain.
Database links:Entrez Gene: 4656 Human
Entrez Gene: 17928 Mouse
Entrez Gene: 497618 Pig
Entrez Gene: 29148 Rat
Omim: 159980 Human
SwissProt: P15173 Human
SwissProt: P12979 Mouse
SwissProt: P49812 Pig
SwissProt: P20428 Rat
Unigene: 2830 Human
Unigene: 16528 Mouse
Unigene: 9465 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
MYOG是肌肉中运载氧的蛋白质，由153个氨基酸残基组成，一种小分子蛋白质，含有血红素，和血红蛋白同源，与氧的结合能力介于血红蛋白和细胞色素氧化酶之间，可帮助肌细胞将氧转运到线粒体。肌细胞生成素在成肌分化过程中起着决定性的作用。在人体骨骼肌的胚胎发育过程中 ,肌细胞生成素伴随成肌过程而呈高水平表达。MYOG主要由肾脏代谢并排泄，当心肌或横纹肌有损伤时，肌红蛋白便释放入血中，血清中的肌红蛋白即可明显升高。