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货号： bs-3542R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3542R-Cy7
- 英文名称
- Anti-DEM1/PNK/Cy7
- 中文名称
- Cy7标记的多聚合苷酸激酶3磷酸化酶抗体
- 别 名
- PNK1; Bifunctional polynucleotide phosphatase/kinase; DEM 1; DEM1; DNA 5 kinase/3 phosphatase; PNK 1; PNK; PNK1; PNKP; Polynucleotide 5 hydroxyl kinase; Polynucleotide kinase 3 prime phosphatase; Polynucleotide kinase 3 phosphatase; Polynucleotide Kinase; PNKP_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Cow, Sheep,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 57kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PNK1/PNKP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Mammalian PNK catalyzes the phosphorylation of DNA at 5-hydroxyl termini and can dephosphorylate its 3-phosphate termini. It plays an important function in DNA repair following ionizing radiation or oxidative damage.PNK has been reported to participate in the repair of DNA-double strand breaks via PARP-1-dependent nonhomologous end-joining.
Function:
Plays a key role in the repair of DNA damage,functioning as part of both the non-homologous end-joining (NHEJ)and base excision repair (BER) pathways. Through its two catalyticactivities, PNK ensures that DNA termini are compatible withextension and ligation by either removing 3-phosphates from, or byphosphorylating 5-hydroxyl groups on, the ribose sugar of the DNAbackbone.
Subunit:
Monomer (By similarity).
Subcellular Location:
Nucleus.
Tissue Specificity:
Expressed in many tissues with highestexpression in spleen and testis, and lowest expression in smallintestine (PubMed:10446192). Expressed in higher amount inpancreas, heart and kidney and at lower levels in brain, lung andliver (PubMed:10446193).
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
DISEASE:
Defects in PNKP are the cause of epilepticencephalopathy, early infantile, type 10 (EIEE10) [MIM:613402]. Adisease characterized by microcephaly, infantile-onset seizures,severe intellectual disability and delayed motor milestones withabsent speech or only achieving a few words. Most patients alsohave behavioral problems with hyperactivity. Microcephaly isprogressive and without neuronal migration or structuralabnormalities, consistent with primary microcephaly.
Similarity:
In the N-terminal section; belongs to the DNA 3phosphatase family.
Contains 1 FHA domain.
Database links:Entrez Gene: 11284 Human
Omim: 605610 Human
SwissProt: Q96T60 Human
Unigene: 78016 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.