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货号： bs-3440R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-3440R-Cy7
- 英文名称
- Anti-Phospho-TBK1 (Ser172)/Cy7
- 中文名称
- Cy7标记的磷酸化NF-κB活化激酶抗体
- 别 名
- NAK (phospho S172); Phospho-TBK1/NAK (Ser172); P-TBK1(Ser172); p-NAK(Ser172); TRAF-associated NF-κB kinase; TANK protein; TANK-binding kinase 1; T2K; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1; I TRAF; ITRAF; TRAF family member associated NF KAPPA B activator; TRAF family member associated NFKB activator; TRAF interacting protein; TRAF interacting protein TANK isoform a; TRAF interacting protein TANK isoform b; TRAF2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 84kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated Synthesised phosphopeptide derived from human TBK1 around the phosphorylation site of Ser172
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. Ubiquitous with higher expression in testis. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Subunit:
Self-associates. Interacts with TIRAP, TANK and TRAF2. Part of a ternary complex consisting of TANK, TRAF2 and TBK1.
Subcellular Location:
Cytoplasm.
Tissue Specificity:
Ubiquitous with higher expression in testis.
Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.
Contains 1 protein kinase domain.
Contains 1 ubiquitin-like domain.
Database links:Entrez Gene: 29110Human
Entrez Gene: 56480Mouse
Entrez Gene: 299827Rat
Omim: 604834Human
SwissProt: Q9UHD2Human
SwissProt: Q9WUN2Mouse
Unigene: 505874Human
Unigene: 34580Mouse
Unigene: 30683Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TBK1是NF-κB信号通道中的一种激酶，它是被KRAS-改变的细胞存活所必不可少的。TBK1诱导反凋亡信号，TBK1与NF-κB共同作用于KRAS介导的癌变过程中,可能是一个癌症治疗目标。