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货号： bs-5107R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5107R-Cy7
- 英文名称
- Anti-PON1/Cy7
- 中文名称
- Cy7标记的芳香酯酶1(对氧磷酶)抗体
- 别 名
- A esterase 1; A-esterase 1; Aromatic esterase 1; Arylesterase B type; ESA; Esterase A; K 45; K-45; MVCD5; Paraoxonase 1; Paraoxonase; Paraoxonase B type; Paraoxonase1; PON 1; PON; PON1;PON-1; PON1_HUMAN; Serum aryldiakylphosphatase; Serum aryldialkylphosphatase 1; Serum paraoxonase/arylesterase 1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 心血管 细胞生物 免疫学 神经生物学 脂蛋白 新陈代谢
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PON1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
PON1 is synthesized primarily in the liver, and a portion is secreted into the plasma, where it is associated with high density lipoproteins (HDL). PON1 hydrolyzes the active metabolites of several other organophosphorus insecticides, as well as nerve agents such as sarin, soman and VX (lethal nerve agent). The PON1 polymorphism may be responsible for neurodegeneration and is considered to be an independent risk factor for Parkinson’s disease.
Function:
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Subunit:
Homodimer. Heterooligomer with phosphate-binding protein (HPBP). Interacts with CLU.
Subcellular Location:
Secreted, extracellular space.
Tissue Specificity:
Plasma, associated with HDL (at protein level). Expressed in liver, but not in heart, brain, placenta, lung, skeletal muscle, kidney or pancreas.
Post-translational modifications:
Glycosylated.
The signal sequence is not cleaved.
Present in two forms, form B contains a disulfide bond, form A does not.
DISEASE:
Microvascular complications of diabetes 5 (MVCD5) [MIM:612633]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. Homozygosity for the Leu-55 allele is strongly associated with the development of retinal disease in diabetic patients.
Similarity:
Belongs to the paraoxonase family.
Database links:Entrez Gene: 5444Human
Entrez Gene: 18979Mouse
Entrez Gene: 84024Rat
Omim: 168820Human
SwissProt: P27169Human
SwissProt: P52430Mouse
SwissProt: P55159Rat
Unigene: 370995Human
Unigene: 237657Mouse
Unigene: 20732Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.