产品中心
当前位置：首页>产品中心Anti-CNR2/Cy7
货号： bs-2377R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-2377R-Cy7
- 英文名称
- Anti-CNR2/Cy7
- 中文名称
- Cy7标记的钙粘蛋白相关的神经受体2抗体
- 别 名
- Cannabinoid receptor 2; Cannabinoid Receptor II; Cannabinoid receptor 2 macrophage; CB 2; CB-2; CB2; CNR2; CNRII; CNR-2; CNR 2; CX 5; CX5; CNR2_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 神经生物学 细胞膜受体
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CNR2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The cannabinoid delta-9-tetrahydrocannabinol is the principal psychoactive ingredient of marijuana. The proteins encoded by this gene and the cannabinoid receptor 1 (brain) (CNR1) gene have the characteristics of a guanine nucleotide-binding protein (G-protein)-coupled receptor for cannabinoids. They inhibit adenylate cyclase activity in a dose-dependent, stereoselective, and pertussis toxin-sensitive manner. These proteins have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. The cannabinoid receptors are members of family 1 of the G-protein-coupled receptors. [provided by RefSeq, Jul 2008].
Function:
Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
Subcellular Location:
Cell membrane. Cell projection, dendrite. Perikaryon. Localizes to apical dendrite of pyramidal neurons.
Tissue Specificity:
Preferentially expressed in cells of the immune system with higher expression in B cells and NK cells (at protein level). Expressed in skin in suprabasal layers and hair follicles (at protein level). Highly expressed in tonsil and to a lower extent in spleen, peripheral blood mononuclear cells, and thymus. PubMed:14657172 could not detect expression in normal brain. Expressed in brain by perivascular microglial cells and dorsal root glanglion sensory neurons (at protein level).
Post-translational modifications:
Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 1269 Human
Entrez Gene: 12802 Mouse
Entrez Gene: 57302 Rat
Omim: 605051 Human
SwissProt: P34972 Human
SwissProt: P47936 Mouse
SwissProt: Q9QZN9 Rat
Unigene: 73037 Human
Unigene: 297251 Mouse
Unigene: 48776 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
大麻素受体2(大麻素II型受体)CB2受体在正常皮肤主要分布于上皮细胞、巨噬细胞、肥大细胞、感觉神经纤维、毛囊、汗腺等部位, 参与皮肤感觉传导、疼痛机制、皮肤免疫、皮肤肿瘤、细胞分化等重要的生理病理过程.