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货号： bs-5118R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5118R-Cy7
- 英文名称
- Anti-TUBA1C/Cy7
- 中文名称
- Cy7标记的微管相关蛋白α6抗体
- 别 名
- Alpha tubulin 6; Alpha tubulin isotype M alpha 6; bcm948; M[a]6; TUBA1C; Tubulin alpha 1C chain; Tubulin alpha-1C chain; tubulin alpha 6; Tubulin alpha 6 chain; tubulin, alpha 1c; TBA1C_HUMAN; Alpha-tubulin 6; Tubulin alpha-6 chain.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 49kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Tubulin alpha 6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Function:
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.
Subunit:
Dimer of alpha and beta chains.
Subcellular Location:
Cytoplasm, cytoskeleton.
Post-translational modifications:
Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
Acetylation of alpha chains at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
Similarity:
Belongs to the tubulin family.
Database links:Entrez Gene: 84790Human
Entrez Gene: 504244Cow
Entrez Gene: 22146Mouse
Entrez Gene: 300218Rat
SwissProt: Q3ZCJ7Cow
SwissProt: Q9BQE3Human
SwissProt: P68373Mouse
SwissProt: Q6AYZ1Rat
Unigene: 725987Human
Unigene: 88212Mouse
Unigene: 154526Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.