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货号： bs-5132R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5132R-Cy7
- 英文名称
- Anti-Unrip/Cy7
- 中文名称
- Cy7标记的丝氨酸/苏氨酸激酶受体相关蛋白抗体
- 别 名
- MAP activator with WD repeats; MAWD; PTWD; serine/threonine kinase receptor associated protein; STRAP; UNR-interacting protein; UNRIP; WD 40 repeat protein PT WD; STRAP_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 染色质和核信号 转录调节因子 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 38kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Unrip
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Unrip is part of the SMN complex that plays a role in snRNP assembly in the cytoplasm and pre mRNA splicing in the nucleus. Unrip interacts directly with Gemin 6 and Gemin 7 in the SMN complex. It is associated with the complex in the cytoplasm but not in the nucleus and thus is thought to play a role in its subcellular localisation.It is a ubiquitously expressed protein that acts as an inhibitor of TGF-beta signaling and an important regulator of cell proliferation. Stable expression of STRAP results in activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway and in down-regulation of the cyclin-dependent kinase inhibitor p21 (Cip1), which results in retinoblastoma protein hyperphosphorylation. Upregulation of STRAP might play a role in tumor development as an early event for colorectal cancers. It is the first component of the U snRNP assembly machinery that associates with SMN complex in a compartment-specific way and plays a crucial role in the intracellular distribution of SMN1.
Function:
The SMN complex plays an essential role in spliceosomalsnRNP assembly in the cytoplasm and is required for pre-mRNAsplicing in the nucleus. STRAP may play a role in the cellulardistribution of the SMN complex. Negatively regulates TGF-betasignaling but positively regulates the PDPK1 kinase activity byenhancing its autophosphorylation and by significantly reducing theassociation of PDPK1 with 14-3-3 protein.
Subunit:
Part of the core SMN complex that contains SMN1,GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8and STRAP/UNRIP. Binds directly to GEMIN6 and GEMIN7. Associateswith the complex in the cytoplasm but not in the nucleus. Alsointeracts with CSDE1/UNR and MAWBP. Interacts with PDPK1.
Subcellular Location:
Cytoplasm. Nucleus. Note=Localizedpredominantly in the cytoplasm but also found in the nucleus.
Similarity:
Belongs to the WD repeat STRAP family.
Contains 7 WD repeats.
Database links:Entrez Gene: 11171Human
Omim: 605986Human
SwissProt: Q9Y3F4Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.