产品中心
当前位置：首页>产品中心Anti-TG/Cy7
货号： bs-0291R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-0291R-Cy7
- 英文名称
- Anti-TG/Cy7
- 中文名称
- Cy7标记的兔抗甲状腺球蛋白
- 别 名
- Thyroglobulin; AITD 3; AITD3; hTG; TDH3; Tg; Tgn; THYG_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Cat,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 660kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- Thyroglobulin protein
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimotos thyroiditis, Graves diseases), with the highest level observed in Hashimotos thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.
Function:
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Subunit:
Homodimer.
Subcellular Location:
Secreted.
Tissue Specificity:
Thyroid gland specific.
Post-translational modifications:
Sulfated tyrosines are desulfated during iodination.
DISEASE:
Defects in TG are the cause of thyroid dyshormonogenesis 3 (TDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
Similarity:
Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.
Database links:Entrez Gene: 7038 Human
Entrez Gene: 21819 Mouse
Entrez Gene: 24826 Rat
Omim: 188450 Human
SwissProt: P01266 Human
SwissProt: O08710 Mouse
SwissProt: P06882 Rat
Unigene: 654591 Human
Unigene: 441333 Mouse
Unigene: 10429 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.