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货号： bs-5158R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5158R-Cy7
- 英文名称
- Anti-Cystatin B/Cy7
- 中文名称
- Cy7标记的胱抑素B/半胱氨酸蛋白酶抑制剂B抗体
- 别 名
- CPI B; CPI-B; CST6; CSTB; Cystatin B; Cystatin-B; CYTB; EPM1; Liver thiol proteinase inhibitor; PME; STFB; CHROW21; CYTB_HUMAN; EPM1A; Stefin-B; ULD.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 14kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human Cystatin B
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008]
Function:
Shows moderate inhibition of cathepsin B but is not active against cathepsin C.
Subcellular Location:
Cytoplasm. Nucleus.Secreted.
Tissue Specificity:
Restricted to the stratum granulosum of normal skin, the stratum granulosum/spinosum of psoriatic skin, and the secretory coils of eccrine sweat glands. Low expression levels are found in the nasal cavity.
Post-translational modifications:
Substrate for transglutaminases. Acts as an acyl acceptor but not as an acyl donor.
Similarity:
Belongs to the cystatin family.
Database links:Entrez Gene: 1476Human
Entrez Gene: 13014Mouse
Entrez Gene: 25308Rat
Omim: 601145Human
SwissProt: P04080Human
SwissProt: Q76LA1Human
SwissProt: Q62426Mouse
SwissProt: P01041Rat
Unigene: 695Human
Unigene: 6095Mouse
Unigene: 1233Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.