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货号： bs-5164R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-5164R-Cy7
- 英文名称
- Anti-ETS1 associated protein II/Cy7
- 中文名称
- Cy7标记的ETS1相关蛋白2抗体
- 别 名
- EAP 2; EAP II; EAP2; EAPII; ETS 1 associated protein 2; ETS 1 associated protein II; ETS1 associated protein 2; ETS1-associated protein 2; ETS1-associated protein II; tdp2; TRAF and TNF receptor associated protein; TRAF and TNF receptor-associated protein; TTRAP; TYDP2_HUMAN; Tyr DNA phosphodiesterase 2; Tyr-DNA phosphodiesterase 2; Tyrosyl DNA phosphodiesterase 2; Tyrosyl-DNA phosphodiesterase 2; 5-Tyr-DNA phosphodiesterase; 5-tyrosyl-DNA phosphodiesterase; AD 022; AD022; MGC111021; MGC9099.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 信号转导 转录调节因子
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 41kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ETS1 associated protein II/EAPII
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5-phosphodiester bond, giving rise to DNA with a free 5 phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5-phosphoglycolates on protruding 5 ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a clean DSB with 5-phosphate termini that are ready for ligation. Has also 3-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Function:
DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5-phosphodiester bond, giving rise to DNA with a free 5 phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. Hydrolyzes 5-phosphoglycolates on protruding 5 ends on DNA double-strand breaks (DSBs) due to DNA damage by radiation and free radicals. The 5-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DSBs without the need for nuclease activity, creating a clean DSB with 5-phosphate termini that are ready for ligation. Has also 3-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. May also act as a negative regulator of ETS1 and may inhibit nuclear factor-kappa-B activation.
Subunit:
Interacts with TRAF2, TRAF3, TRAF5, TRAF6, TNFRSF8/CD30, TNFRSF5/CD40, TNFRSF1B/TNF-R75, ETS1, ETS2, FLI1, SMAD3 and ACVR1B/ALK4.
Subcellular Location:
Nucleus. Nucleus, PML body.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the CCR4/nocturin family.
Database links:Entrez Gene: 51567Human
Omim: 605764Human
SwissProt: O95551Human
Unigene: 728795Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.