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货号： bs-4113R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4113R-Cy7
- 英文名称
- Anti-HMG14/Cy7
- 中文名称
- Cy7标记的高迁移率核小体结合蛋白1
- 别 名
- High mobility group (nonhistone chromosomal) protein 14; High mobility group nucleosome binding 1; High mobility group nucleosome binding domain containing protein 1; High mobility group protein 14; High-mobility group nucleosome binding domain 1; HMG14; HMGN 1; HMGN1; MGC104230; MGC117425; Nonhistone chromosomal protein HMG-14; Nonhistone chromosomal protein HMG14; FLJ27265; FLJ31471.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 染色质和核信号 神经生物学 细胞周期蛋白 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 11kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human HMG14
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
Function:
Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2.
Subcellular Location:
Nucleus. Cytoplasm. Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
Post-translational modifications:
Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization.
Similarity:
Belongs to the HMGN family.
Database links:Entrez Gene: 3150Human
Entrez Gene: 614915Cow
Entrez Gene: 100044391Mouse
Entrez Gene: 15312Mouse
Omim: 163920Human
SwissProt: P02316Cow
SwissProt: P05114Human
SwissProt: P18608Mouse
Unigene: 87121Cow
Unigene: 356285Human
Unigene: 702472Human
Unigene: 2756Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
HMGN1是一个核仁结合蛋白, 属于核小体结合高速迁移蛋白家族(A family of High Mobility Group Proteins that bind to Nucleosomesn, HMGN)含量蛋白较高,能稳定染色质的二级结构, 修复紫外线诱导的染色质DNA损伤。
HMGN1的缺失可导致细胞增殖和生长发生紊乱, 通过打乱细胞的生长控制机制使一些致癌因素更为敏感并发生恶性转化。 研究表明, HMGN1在细胞核内是动态表达的，与细胞的新陈代谢有关。HMGN1蛋白和核仁的相互作用可改变染色质的结构, 并且能调节各种与DNA相关的包括转录的细胞核作用。