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货号： bs-4608R-Cy7 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-4608R-Cy7
- 英文名称
- Anti-CUEDC2/Cy7
- 中文名称
- Cy7标记的CUE结构域蛋白2抗体
- 别 名
- bA18I14.5; C10orf66; Chromosome 10 open reading frame 66; CUE domain containing 2; CUE domain-containing protein 2; CUED2; CUED2_HUMAN; Cuedc2; MGC2491; OTTHUMP00000020368.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 免疫学 染色质和核信号 信号转导 激酶和磷酸酶 表观遗传学 泛素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
- 产品应用
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 32kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human CUE doma
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Controls PGR and ESR1 protein levels through their targeting for ubiquitination and subsequent proteasomal degradation.
Function:
Down-regulates ESR1 protein levels through the ubiquitination-proteasome pathway, regardless of the presence of 17 beta-estradiol. Also involved in 17 beta-estradiol-induced ESR1 degradation. Controls PGR protein levels through a similar mechanism.
Subunit:
Interacts with PGR. Interacts with ESR1 in the presence or absence of 17 beta-estradiol.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Significantly up-regulated in breast tumor tissues compared with matched adjacent normal tissues (at protein level). Levels inversely correlate with ESR1 in breast cancers and are lower in low-grade tumors compared to high-grade tumors.
DISEASE:
Note=May predict the clinical outcome of tamoxifen therapy of breast cancer patients. Patients with tumors that highly express CUEDC2 do not respond to tamoxifen treatment as effectively as those with tumors with low expression.
Similarity:
Belongs to the CUEDC2 family.
Contains 1 CUE domain.
Database links:Entrez Gene: 79004Human
Entrez Gene: 67116Mouse
Entrez Gene: 294009Rat
Omim: 614142Human
SwissProt: Q9H467Human
SwissProt: Q9CXX9Mouse
SwissProt: A1L131Rat
Unigene: 500874Human
Unigene: 218848Mouse
Unigene: 19673Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
CUEDC2(CUE Domain Containing 2)能够结合IKKα和IKKβ,并通过使IKKα和IKKβ去磷酸化而抑制NF-κ信号通路。CUEDC2能特异性结合雌激素受体（ER），并导致ER的泛素化降解.抑制乳腺癌细胞的生长。