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货号： bsm-51265M 基本售价： 860.0 元 规格： 50ul
- 规格：50ul
- 价格：860.00元
- 规格：100ul
- 价格：1580.00元
产品信息
- 产品编号
- bsm-51265M
- 英文名称
- PINK1
- 中文名称
- 小鼠抗肿瘤相关胰蛋白酶抑制剂1单克隆抗体
- 别 名
- PINK1_HUMAN; PTEN Induced Putative Kinase 1; PTEN-Induced Putative Kinase Protein 1; BRPK; Serine/Threonine-Protein Kinase PINK1, Mitochondrial; Parkinson Disease (Autosomal Recessive) 6; Protein Kinase BRPK; EC 2.7.11.1; PARK6;
- 规格价格
- 50ul/860元购买 100ul/1580元购买 大包装/询价
- 说 明 书
- 50ul 100ul
- 研究领域
- 信号转导 激酶和磷酸酶 线粒体
- 抗体来源
- Mouse
- 克隆类型
- Monoclonal
- 克 隆 号
- 5C6
- 交叉反应
- Human, Mouse,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:20-100 IF=1:20-100 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 63kDa
- 细胞定位
- 细胞浆 线粒体
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- Recombinant human PINK1 protein:
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein G
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]
Function:
Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PRKN . Targets PRKN to dysfunctional depolarized mitochondria through the phosphorylation of MFN2 . Activates PRKN in 2 steps: (1) by mediating phosphorylation at Ser-65 of PRKN and (2) mediating phosphorylation of ubiquitin, converting PRKN to its fully-active form . Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity).
Subunit:
Interacts with PRKN. Interacts with FBXO7. Forms a complex with PRKN and PARK7.
Subcellular Location:
Localizes mostly in mitochondrion and the 2 proteolytic processed fragments of 55 kDa and 48 kDa localize mainly in cytosol.
Tissue Specificity:
Highly expressed in heart, skeletal muscle and testis, and at lower levels in brain, placenta, liver, kidney, pancreas, prostate, ovary and small intestine. Present in the embryonic testis from an early stage of development.
Post-translational modifications:
Autophosphorylation at Ser-228 and Ser-402 is essential for Parkin/PRKN recruitment to depolarized mitochondria.
Two shorter forms of 55 kDa and 48 kDa seem to be produced by proteolytic cleavage and localize mainly in cytosol.
Similarity:
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
SWISS:
Q9BXM7
Gene ID:
65018
Database links:Entrez Gene: 65018 Human
Entrez Gene: 68943 Mouse
Entrez Gene: 298575 Rat
NCBI: 14165272 Human
Omim: 608309 Human
SwissProt: Q9BXM7 Human
SwissProt: Q99MQ3 Mouse
Unigene: 389171 Human
Unigene: 18539 Mouse
Unigene: 219286 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.