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货号： bsm-52239R 基本售价： 1580.0 元 规格： 50ul
- 规格：50ul
- 价格：1580.00元
- 规格：100ul
- 价格：2680.00元
产品信息
- 产品编号
- bsm-52239R
- 英文名称
- STAT6
- 中文名称
- 兔抗信号转导和转录激活因子6单克隆抗体
- 别 名
- signal transducers and activators of transduction 6; D12S1644; IL 4 STAT; IL4 STAT; Interleukin 4 Induced; Interleukin 4 Induced Transcription Factor IL4 STAT; Signal Transducer And Activator Of Transcription 6 Interleukin 4 Induced; Signal Transducer And Activator Of Transcription 6 Nirs Variant 1; STAT 6; STAT interleukin4 induced; STAT6B; STAT6C; Transcription factor IL 4 STAT.
- 规格价格
- 50ul/1580元购买 100ul/2680元购买 大包装/询价
- 说 明 书
- 50ul 100ul
- 研究领域
- 肿瘤 发育生物学 信号转导 细胞凋亡 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Monoclonal
- 克 隆 号
- 9A7
- 交叉反应
- Human, Mouse,
- 产品应用
- WB=1:500-1000 IHC-P=1:20-200 IHC-F=1:20-200 ICC=1:20-200 IF=1:20-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 94kDa
- 细胞定位
- 细胞核 细胞浆
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human STAT6:
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X (L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Function:
Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
Subunit:
Forms a homodimer or a heterodimer with a related family member. Interacts with NCOA1 via its C-terminal LXXLL motif.
Subcellular Location:
Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.
Post-translational modifications:
Tyrosine phosphorylated following stimulation by IL-4 and IL-3.
Similarity:
Belongs to the transcription factor STAT family.
Contains 1 SH2 domain.
SWISS:
P42226
Gene ID:
6778
Database links:Entrez Gene: 6778 Human
Entrez Gene: 20852 Mouse
Entrez Gene: 362896 Rat
Omim: 601512 Human
SwissProt: P42226 Human
SwissProt: P52633 Mouse
Unigene: 524518 Human
Unigene: 121721 Mouse
Unigene: 6880 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.