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货号： bsm-30073M-FITC 基本售价： 980.0 元 规格： 25T
- 规格：25T
- 价格：980.00元
- 规格：100T
- 价格：2380.00元
产品信息
- 产品编号
- bsm-30073M-FITC
- 英文名称
- human CD11b-FITC
- 中文名称
- FITC标记小鼠抗人CD11b单克隆抗体
- 别 名
- Antigen CD11b p170; CD11 antigen like family member B; CD11b antigen; CD49d; Cell surface glycoprotein MAC 1 alpha subunit; Cell Surface Glycoprotein MAC1 Alpha Subunit; Complement Component Receptor 3 Alpha; CR 3 alpha chain; CR3 Alpha Chain; CR3A; Integrin Alpha M; integrin alpha M complement component 3 receptor 3 subunit; Leukocyte Adhesion Receptor MO1; MAC 1; MAC1A; MGC117044; MO1A; Neutrophil Adherence Receptor; Cd11b; CD11b/CD18; F730045J24Rik; Ly-40; ITGAM; CR3A; ITAM_HUMAN; FITC anti-human CD11b;
- 规格价格
- 25T/980元购买 100T/2380元购买 大包装/询价
- 说 明 书
- 25T 100T
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 干细胞 细胞粘附分子 细胞类型标志物 淋巴细胞
- 抗体来源
- Mouse
- 克隆类型
- Monoclonal
- 克 隆 号
- HI11b
- 交叉反应
- Human,
- 产品应用
- Flow-Cyt=10ul/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 125kDa
- 细胞定位
- 细胞膜
- 性 状
- Liquid
- 免 疫 原
- :
- 亚 型
- Mouse IgG1
- 纯化方法
- affinity purified by Protein G
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at 4°C for one year. Avoid repeated freeze/thaw cycles.
- PubMed
- PubMed
- 产品介绍
- background:
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Function:
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.
Subcellular Location:
Membrane.
Tissue Specificity:
Predominantly expressed in monocytes and granulocytes.
Similarity:
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6). Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
SWISS:
P11215
Gene ID:
3684
Database links:Entrez Gene: 3684Human
Omim: 120980Human
SwissProt: P11215Human
Unigene: 172631Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.