| 货号 | 7865S |
| 描述 | SignalSilence® PEA-15 siRNA II from Cell Signaling Technology (CST) allows the researcher to specifically inhibit PEA-15 expression using RNA interference, a method whereby gene expression can be selectively silenced through the delivery of double stranded RNA molecules into the cell. All SignalSilence® siRNA products from CST are rigorously tested in-house and have been shown to reduce target protein expression by western analysis. |
| 反应种属 | Human |
| 应用 | TFN |
| 目标/特异性 | PEA-15 siRNA II inhibits human, mouse, and rat PEA-15 expression. |
| 供应商 | CST |
| 背景 | PEA-15 is a 15 kDa phosphoprotein expressed abundantly in astrocytes and fibroblasts as well as in tissues, including the lung and eye (1). The protein has been shown to coordinate cell growth, death, and glucose ultilization (2-4). The amino-terminal DED domain of PEA-15 mediates its binding to FADD or Erk and futher regulates the Erk and apoptosis signaling pathways. PEA-15 can be phosphorylated at two serine residues, Ser104 and Ser116, located within the carboxy terminus. Phosphorylation at these sites regulates binding to Erk and FADD (2,3). |
| 存放说明 | -20C |
| 参考文献 | Danziger, N. et al. (1995) J. Neurochem. 64, 1016-1025. Krueger, J. et al. (2005) Mol. Biol. Cell 16, 3552-3561. Renganathan, H. et al. (2005) Biochem. J. 390, 729-735. Condorelli, G. et al. (1998) EMBO J. 17, 3858-3866. |
