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货号： bs-19928R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19928R-Cy5.5
- 英文名称
- Anti-phospho-SMC3 (Ser1083)/Cy5.5
- 中文名称
- Cy5.5标记的磷酸化基底膜相关软骨素蛋白多糖抗体
- 别 名
- SMC3 (phospho S1083); p-SMC3 (phospho S1083); CDLS2; DKFZp686L19178; DXhXs423e; DXS423E; KIAA0178; MGC138332; OTTHUMP00000061876; RP6 29D12.1; SB1.8; Segregation of mitotic chromosomes 1; Segregation of mitotic chromosomes like 1; SMC 1; SMC protein 1B; SMC-1-beta; SMC-1B; SMC1; SMC1A; SMC1alpha; SMC1alpha protein; SMC1B; SMC1B_HUMAN; SMC1BETA; SMC1beta protein; SMC1L1; SMC1L2; SMCB; Structural maintenance of chromosome 1 like 1 protein; Structural maintenance of chromosome 1 like 2 protein; Structural maintenance of chromosomes 1A; Structural maintenance of chromosomes 1B; Structural maintenance of chromosomes protein 1B.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 产品类型
- 磷酸化抗体
- 研究领域
- 肿瘤 细胞生物 信号转导 细胞周期蛋白 转录调节因子 表观遗传学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 141kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthesised phosphopeptide derived from human SMC3 around the phosphorylation site of Ser1083.
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]
Function:
Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex plays also an important role in spindle pole assembly during mitosis and in chromosomes movement.
Subcellular Location:
Nucleus. Chromosome. Chromosome > centromere. Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation.
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.
Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication.
DISEASE:
Defects in SMC3 are the cause of Cornelia de Lange syndrome type 3 (CDLS3) [MIM:610759]. CDLS is a dominantly inherited multisystem developmental disorder characterized by growth and cognitive retardation, abnormalities of the upper limbs, gastroesophageal dysfunction, cardiac, ophthalmologic and genitourinary anomalies, hirsutism, and characteristic facial features. CDSL3 is a mild form with absence of major structural anomalies typically associated with CDLS. The phenotype in some instances approaches that of apparently non-syndromic mental retardation.
Similarity:
Belongs to the SMC family. SMC3 subfamily.
Database links:Entrez Gene: 395188Chicken
Entrez Gene: 281729Cow
Entrez Gene: 9126Human
Entrez Gene: 13006Mouse
Entrez Gene: 29486Rat
Entrez Gene: 399092 Xenopus laevis
Entrez Gene: 324475Zebrafish
Omim: 606062Human
SwissProt: Q9UQE7Human
SwissProt: Q9CW03Mouse
SwissProt: P97690Rat
SwissProt: O93309 Xenopus laevis
Unigene: 24485Human
Unigene: 14910Mouse
Unigene: 11074Rat
Unigene: 290 Xenopus laevis
Unigene: 75355 Xenopus laevis
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.