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货号： bsm-0389M 基本售价： 860.0 元 规格： 50ul
- 规格：50ul
- 价格：860.00元
- 规格：100ul
- 价格：1580.00元
产品信息
- 产品编号
- bsm-0389M
- 英文名称
- IL-2
- 中文名称
- 白细胞介素-2单克隆抗体
- 别 名
- Interleukin-2; T-cell growth factor; Aldesleukin; IL 2; Interleukin 2; Interleukin2; Lymphokine; POIL2; T Cell Growth Factor; TCGF.
- Specific References (1) | bsm-0389M has been referenced in 1 publications.[IF=3.17] Zhang, Jia‐xiang, et al. "Complement C5a–C5aR interaction enhances MAPK signaling pathway activities to mediate renal injury in trichloroethylene sensitized BALB/c mice." Journal of Applied Toxicology (2015). IHC-P ; Mouse.PubMed:26095957
- 规格价格
- 50ul/860元购买 100ul/1580元购买 大包装/询价
- 说 明 书
- 50ul 100ul
- 研究领域
- 免疫学 糖蛋白
- 抗体来源
- Mouse
- 克隆类型
- Monoclonal
- 克 隆 号
- H2E4
- 交叉反应
- Human,
- 产品应用
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 15kDa
- 细胞定位
- 分泌型蛋白
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- Recombinant human IL-2:21-153/153
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein G
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
Function:
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells.
Subcellular Location:
Secreted.
DISEASE:
Note=A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17.
Similarity:
Belongs to the IL-2 family.
SWISS:
P60568
Gene ID:
3558
Database links:Entrez Gene: 3558 Human
Entrez Gene: 16183 Mouse
Entrez Gene: 116562 Rat
Omim: 147680 Human
SwissProt: P60568 Human
SwissProt: P04351 Mouse
SwissProt: P17108 Rat
Unigene: 89679 Human
Unigene: 14190 Mouse
Unigene: 9871 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
IL-2作为一种T细胞生长因子在免疫应答及其调节中起重要作用,IL-2的拮抗剂可用于同种移植排斥、T细胞性白血病以及某些自身免疫性疾病的治疗.胞内IL-2的水平是反映Th1 /Th2型细胞平衡状态的一个有用指标,血清IL-2的水平异常增高与某些疾病密切相关