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货号： bs-19576R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-19576R-Cy5.5
- 英文名称
- Anti-PSME2/Cy5.5
- 中文名称
- Cy5.5标记的蛋白酶激活复合物亚基2抗体
- 别 名
- 11S regulator complex beta subunit; 11S regulator complex subunit beta; Activator of multicatalytic protease subunit 2; Cell migration inducing protein 22; MCP activator 31 kD subunit; PA28 beta; PA28B; PA28beta; Proteasome (prosome macropain) activator subunit 2 (PA28 beta); Proteasome (prosome macropain) activator subunit 2; Proteasome activator 28 beta; Proteasome activator 28 subunit beta; Proteasome activator complex subunit 2; Proteasome activator hPA28 subunit beta; Proteasome activator subunit 2; PSME 2; PSME2; PSME2_HUMAN; REG beta; REG-beta; REGbeta.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 泛素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 27kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human PSME2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]
Function:
Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome.
Subunit:
Heterodimer of PSME1 and PSME2, which forms a hexameric ring.
Similarity:
Belongs to the PA28 family.
Database links:Entrez Gene: 5721Human
Entrez Gene: 509857Cow
Entrez Gene: 480258Dog
Entrez Gene: 101836765Hamster
Entrez Gene: 100051729Horse
Entrez Gene: 19188Mouse
Entrez Gene: 397522Pig
Entrez Gene: 100362709Rat
Entrez Gene: 100364216Rat
Entrez Gene: 29614Rat
Entrez Gene: 30647Zebrafish
Omim: 602161Human
SwissProt: Q5E9G3Cow
SwissProt: Q9UL46Human
SwissProt: P97372Mouse
SwissProt: Q863Z0Pig
SwissProt: Q63798Rat
Unigene: 434081Human
Unigene: 512410Human
Unigene: 371573Mouse
Unigene: 127779Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.