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货号： bsm-30078M-APC 基本售价： 1584.0 元 规格： 25T
- 规格：25T
- 价格：1584.00元
- 规格：100T
- 价格：3600.00元
产品信息
- 产品编号
- bsm-30078M-APC
- 英文名称
- human CD33-APC
- 中文名称
- APC标记小鼠抗人CD33单克隆抗体
- 别 名
- CD33_HUMAN; CD 33; CD33 antigen; CD33 molecule; FLJ00391; gp67 ; Myeloid cell surface antigen CD33; Myeloid cell surface antigen CD33 precursor; p67 ; Sialic acid binding Ig like lectin 3; Sialic acid binding immunoglobulin like lectin 3; SIGLEC3; Siglec-3; myeloid cell surface antigen CD33 isoform 1 precursor. APC anti-human CD33;
- 规格价格
- 25T/1584元购买 100T/3600元购买 大包装/询价
- 说 明 书
- 25T 100T
- 研究领域
- 免疫学 干细胞 细胞表面分子
- 抗体来源
- Mouse
- 克隆类型
- Monoclonal
- 克 隆 号
- HI33a
- 交叉反应
- Human,
- 产品应用
- Flow-Cyt=20ul/Test （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40/37kDa
- 细胞定位
- 细胞膜
- 性 状
- Liquid
- 免 疫 原
- :
- 亚 型
- IgG2a
- 纯化方法
- affinity purified by Protein G
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- PubMed
- PubMed
- 产品介绍
- background:
CD33 is found on granulocyte and macrophage precursors in the bone marrow, but is not on pluripotent stem cells. The protein is also expressed on, and is a useful marker for, peripheral monocytes. It is also useful for distinguishing myelogenous leukaemia cells from lymphoid or erythroid leukaemias.
Function:
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
Subunit:
Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity:
Monocytic/myeloid lineage cells.
Post-translational modifications:
Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11.
Phosphorylation of Tyr-358 is involved in binding to PTPN6.
Similarity:
Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
P20138
Gene ID:
945
Database links:Entrez Gene: 945 Human
Omim: 159590 Human
SwissProt: P20138 Human
Unigene: 83731 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
- 产品图片
Flow cytometry staining of normal human peripheral blood cells with CD33/APC(bsm-30078M-APC)(Red histogram) or Mouse IgG2a Isotype Control (APC Conjugate)(C03-12004)(Blue histogram) . Total cells were used for analysis.