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货号： bs-18601R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18601R-Cy5.5
- 英文名称
- Anti-LZTS2/Cy5.5
- 中文名称
- Cy5.5标记的亮氨酸拉链抑癌蛋白2抗体
- 别 名
- hLZTS2; KIAA1813; LAPSER1; Leucine zipper putative tumor suppressor 2; LZTS2; LZTS2_HUMAN; OTTHUMP00000020289; Protein LAPSER1; RP11-108L7.8.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 73kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LZTS2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
LAPSER1 is a member of the LZTS family. Due to its deletion in multiple cancers, including prostate tumors, LAPSER1 is purported to be a tumor suppressor. In cancer cell lines, the overexpression of LAPSER1 can lead to growth inhibition and colony-forming efficiency. LAPSER1 is highly expressed in testis and prostate, but can be detected at lower levels in spleen, thymus, uterus, small intestine and colon. LAPSER1 colocalizes with ?tubulin, MKLP-1 and p80 katanin. LAPSER1 is involved in cytokinesis. The disruption of LAPSER1, which is accompanied by the mislocalization of p80 katanin, results in malformation of the central spindle. This is a potential impetus for carcinogenesis.
Function:
Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin.
Subcellular Location:
Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
Tissue Specificity:
Highly expressed in prostate and testis, and at slightly lower levels in spleen, thymus, uterus, small intestine and colon.
Similarity:
Belongs to the LZTS2 family.
Database links:Entrez Gene: 504411Cow
Entrez Gene: 84445Human
Entrez Gene: 226154Mouse
Entrez Gene: 365468Rat
Omim: 610454Human
SwissProt: A5PKL7Cow
SwissProt: Q9BRK4Human
SwissProt: Q91YU6Mouse
SwissProt: Q3LUD4Rat
Unigene: 523221Human
Unigene: 28204Mouse
Unigene: 23951Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.