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货号： bs-18366R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18366R-Cy5.5
- 英文名称
- Anti-LRP5 + LRP6/Cy5.5
- 中文名称
- Cy5.5标记的低密度脂蛋白受体相关蛋白5+6抗体
- 别 名
- BMND 1; BMND1; EVR 1; EVR 4; EVR1; EVR4; FLJ90062; FLJ90421; HBM; LDL Receptor Related Protein 5 + 6; Low density lipoprotein receptor related protein 5; Low density lipoprotein receptor related protein 5 precursor; Low density lipoprotein receptor related protein 6; Low density lipoprotein receptor related protein 6 precursor; LR 3; LR3; LRP 5; LRP 6; LRP 7; LRP7; OPPG; OPS; OPTA 1; OPTA1; VBCH 2; VBCH2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 肿瘤 细胞生物 神经生物学 信号转导 细胞膜受体 细胞膜蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Pig, Cow, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 176kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LRP5 + LRP6
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
Subcellular Location:
Membrane; single-pass type I membrane protein
Similarity:
Belongs to the LDLR family.
Contains 4 EGF-like domains.
Contains 3 LDL-receptor class A domains.
Contains 20 LDL-receptor class B repeats.
Database links:Entrez Gene: 4040Human
Entrez Gene: 4041Human
Entrez Gene: 16973Mouse
Entrez Gene: 16974Mouse
Omim: 603506Human
Omim: 603507Human
SwissProt: O75197Human
SwissProt: O75581Human
SwissProt: O88572Mouse
SwissProt: Q91VN0Mouse
Unigene: 45360Human
Unigene: 584775Human
Unigene: 6347Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.