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货号： bs-18363R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-18363R-Cy5.5
- 英文名称
- Anti-LRP2BP/Cy5.5
- 中文名称
- Cy5.5标记的低密度脂蛋白相关蛋白2结合蛋白抗体
- 别 名
- DKFZp761O0113; FLJ44965; KIAA1325; LR2BP_HUMAN; LRP2 binding protein; LRP2-binding protein; Lrp2bp; Megalin binding protein; Megalin-binding protein; MegBP.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 40kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human LRP2BP
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
LRP2BP is a 347 amino acid protein that contains one TPR repeat and six Sel1-like repeats. Localized to the plasma membrane and throughout the cytoplasm, LRP2BP interacts with megalin (also known as LRP2) and, via this interaction, is thought to regulate megalin function. Specifically, LRP2BP acts as a scaffold protein that, through its TPR motifs, assists in the sequestration and/or the release of transcription factors that influence megalin’s affects on endocytosis and hormone release. LRP2BP is expressed in colon, testis, small intestine and blood leukocytes, as well as in pancreatic adenocarcinoma cells, suggesting a possible role for LRP2BP in carcinogenesis. Two isoforms of LRP2BP exist due to alternative splicing events.
Function:
May act as an adapter that regulates LRP2 function.
Subcellular Location:
Cytoplasm. Detected in a vesicular staining pattern close to the plasma membrane and throughout the cytoplasm.
Similarity:
Contains 6 Sel1-like repeats.
Contains 1 TPR repeat.
Database links:Entrez Gene: 55805Human
Entrez Gene: 67620Mouse
Entrez Gene: 290753Rat
Entrez Gene: 100073340Zebrafish
SwissProt: Q9P2M1Human
SwissProt: Q9D4C6Mouse
SwissProt: Q569C2Rat
SwissProt: A5PLI4Zebrafish
Unigene: 558513Human
Unigene: 383914Mouse
Unigene: 108662Rat
Unigene: 94415Zebrafish
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.