Anti-ORMDL1 + ORMDL2 + ORMDL3/Cy5.5【科瑞奥博】

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货号： bs-18035R-Cy5.5 基本售价： 2980.0 元规格： 100ul

产品应用: ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.

免疫原: KLH conjugated synthetic peptide derived from human ORMDL1 + ORMDL2 + ORMDL3

保存条件: Store at -20°C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4°C.

产品介绍: background:
The ORMDL (ORM1-like) family of proteins consist of ORMDL1, ORMDL2 and ORMDL3; all of which are human homologs of the S. cerevisiae ORM1 protein. Localized to the membrane of the endoplasmic reticulum, ORMDLs are multi-pass membrane proteins that are implicated in ?secretase (BACE) function, as well as expression of Presenilin (PSI), a protein involved in Alzheimer抯 disease (AD). ORMDL1 (ORM1-like protein 1), also known as Adoplin-1, is a widely expressed 153 amino acid member of the ORMDL family. Expression of ORMDL1 is down-regulated in PSI mutations, suggesting a possible role as a therapeutic target for AD. ORMDL2 (ORM1-like protein 2), also known as Adoplin-2, and ORMDL3 (ORM1-like protein 3) are expressed in tissues such as heart, brain, lung, liver and kidney. ORMDL3 exists as two isoforms due to alternative splicing events and may be a determinant of susceptibility to childhood asthma

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.