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货号： bs-17747R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17747R-Cy5.5
- 英文名称
- Anti-MR1/Cy5.5
- 中文名称
- Cy5.5标记的组织相容性复合物相关蛋白MR1抗体
- 别 名
- Class I histocompatibility antigen like protein; HLALS; Major histocompatibility complex class I like sequence; Major histocompatibility complex class I related; Major histocompatibility complex class I related gene protein; Major histocompatibility complex class I related isoform CRA a; Major histocompatibility complex class I related isoform CRA c; Major histocompatibility complex class I related isoform CRA d; MHC class I like antigen MR 1; MHC class I like antigen MR1; MHC class I related gene protein; MHC class I related protein 1 isoform B; MHC class I related protein 1 isoform C; MR 1; Mr1 protein; MR1B; MR1C.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 39kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human MR1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
MR1 is a 341 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum, as well as to the extracellular side of the cell membrane, and contains one Ig-like C1-type domain. Expressed ubiquitously, MR1 exists as a heterodimer with β-2-Microglobulin and plays an important role in antigen presentation, specifically in the development and expansion of mucosal-associated invariant T cells (MAITs). MAITs are located in the gut and are involved in monitoring flora levels, as well as in conveying distress signals to other areas of the body, indicating a role for MR1 in proper digestion and immune system function. MR1 exists as four alternatively spliced isoforms and is encoded by a gene which maps to human chromosome 1.
Function:
Similar to a typical class I MHC molecule, the MR1 (MHC-related 1) protein comprises a signal sequence, 3 extracellular domains (alpha-1, alpha-2, and alpha-3), a transmembrane domain, and a cytoplasmic domain. MR1 encodes peptide-binding domains similar to those encoded by HLA class I genes.
Database links:Entrez Gene: 3140Human
Omim: 600764Human
SwissProt: Q95460Human
Unigene: 101840Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.