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货号： bs-17191R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-17191R-Cy5.5
- 英文名称
- Anti-IYD/Cy5.5
- 中文名称
- Cy5.5标记的碘酪氨酸脱碘酶抗体
- 别 名
- C6orf71; DEHAL1; dJ422F24.1; Iodotyrosine dehalogenase 1; iodotyrosine deiodinase; IYD; IYD-1; IYD1_HUMAN; OTTHUMP00000017973; OTTHUMP00000237263; OTTHUMP00000237264; OTTHUMP00000237265; OTTHUMP00000237266; OTTHUMP00000237267; TDH4.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 31kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IYD
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Function:
Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine.
Subcellular Location:
Cell membrane.
Tissue Specificity:
Expressed at a high level in thyroid gland and at lower level in kidney and trachea.
DISEASE:
Defects in IYD are the cause of congenital hypothyroidism due to dyshormonogenesis type 4 (CHDH4) [MIM:274800]; also known as genetic defect in thyroid hormonogenesis type 4 or iodotyrosine dehalogenase deficiency or deiodinase deficiency. Patients with this defect present a phenotype of severe hypothyroidism, goiter, excessive levels of iodotyrosine in serum and urine, and variable mental deficits derived from unrecognized hypothyroidism.
Similarity:
Belongs to the nitroreductase family.
Database links:Entrez Gene: 389434Human
Entrez Gene: 70337Mouse
Entrez Gene: 308129Rat
Omim: 612025Human
SwissProt: Q6PHW0Human
SwissProt: Q9DCX8Mouse
SwissProt: Q5BK17Rat
Unigene: 310225Human
Unigene: 24153Mouse
Unigene: 34836Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.