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货号： bs-16695R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16695R-Cy5.5
- 英文名称
- Anti-IRAKM/Cy5.5
- 中文名称
- Cy5.5标记的白细胞介素1受体相关蛋白激酶M抗体
- 别 名
- ASRT5; IL 1 receptor associated kinase M; IL-1 receptor-associated kinase M; IL1 receptor associated kinase M; Interleukin 1 Receptor Associated Kinase 3; Interleukin 1 Receptor Associated Kinase 3; Interleukin 1 Receptor Associated Kinase M; Interleukin 1 Receptor Associated Kinase M; Interleukin-1 receptor-associated kinase 3; IRAK 3; IRAK 3; IRAK M; IRAK-3; IRAK-M; IRAK3; IRAK3; IRAK3_HUMAN.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 免疫学 信号转导 激酶和磷酸酶
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Pig, Horse, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 68kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human IRAKM
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Function:
Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
Tissue Specificity:
Expressed predominantly in peripheral blood lymphocytes.
DISEASE:
Defects in IRAK3 are associated with susceptibility to asthma-related traits type 5 (ASRT5) [MIM:611064]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
Similarity:
Belongs to the protein kinase superfamily.
TKL Ser/Thr protein kinase family. Pelle subfamily.
Contains 1 death domain.
Contains 1 protein kinase domain.
Database links:Entrez Gene: 11213Human
Entrez Gene: 73914Mouse
Entrez Gene: 314870Rat
Omim: 604459Human
SwissProt: Q9Y616Human
SwissProt: Q8K4B2Mouse
Unigene: 369265Human
Unigene: 146194Mouse
Unigene: 147737Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.