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货号： bs-16412R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-16412R-Cy5.5
- 英文名称
- Anti-ZRANB1/Cy5.5
- 中文名称
- Cy5.5标记的ZRANB1蛋白抗体
- 别 名
- DKFZp762P2216; hTrabid; Trabid; TRAF-binding protein domain; Ubiquitin thioesterase ZRANB1; Zinc finger Ran-binding domain-containing protein 1; ZRAN1_HUMAN; ZRANB1.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 表观遗传学 泛素
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Rabbit,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 81kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human ZRANB1
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 癈 for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20癈. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 癈.
- 产品介绍
- background:
TRABID is a 708 amino acid cytoplasmic and nuclear protein that is widely expressed. Belonging to the peptidase C64 family, TRABID is considered a positive regulator of the Wnt signaling pathway that specifically cleaves Lys-63-linked ubiquitin chains. TRABID acts by deubiquitinating APC, a negative regulator of Wnt-mediated transcription. TRABID contains a OTU domain, which mediates the deubiquitinating activity, and three RanBP2-type zinc fingers that mediate the specific interaction with Lys-63-linked ubiquitin. It is suggested that TRABID may also modulate TNF?signaling. The gene encoding TRABID is located on chromosome 10, which houses over 1,200 genes and comprises nearly 4.5% of the human genome.
Function:
Positive regulator of the Wnt signaling pathway that specifically cleaves Lys-63-linked ubiquitin chains. Acts by deubiquitinating APC protein, a negative regulator of Wnt-mediated transcription. May also modulate TNF-alpha signaling.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the peptidase C64 family.
Contains 1 OTU domain.
Contains 3 RanBP2-type zinc fingers.
Database links:Entrez Gene: 54764Human
Entrez Gene: 360216Mouse
Omim: 611749Human
SwissProt: Q9UGI0Human
SwissProt: Q7M760Mouse
Unigene: 595158Human
Unigene: 389984Mouse
Unigene: 397069Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.