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货号： bs-14665R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14665R-Cy5.5
- 英文名称
- Anti-EXOC8/Cy5.5
- 中文名称
- Cy5.5标记的EXOC8蛋白抗体
- 别 名
- EXO84; Exo84p; exoc8; EXOC8_HUMAN; Exocyst complex 84 kDa subunit; Exocyst complex component 8; SEC84.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 细胞生物 信号转导 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Cow, Horse, Rabbit, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 82kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human EXOC8
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Exocytosis is crucial in membrane trafficking and it mediates hormone and neurotransmitter secretion out of the cell, as well as the incorporation of membrane proteins and lipids to the plasma membrane. It is crucial for cell-cell communication, cell growth and cell polarity. The exocyst complex is a multi-protein complex that consists of Sec3, Sec5, Sec6, Sec8, Sec10, Sec15, Exo70 and Exo84, and is essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. The exocyst complex inhibits tubulin polymerization in vitro, suggesting that the exocyst complex is important for modulating the microtubule dynamics that underlie exocytosis. Exo84 (Exocyst complex 84 kDa subunit), also known as Exocyst complex component 8, is a 725 amino acid protein that is one of eight protein subunits composing the mammalian exocyst complex. Both Exo84 and Sec5 are effector targets for active Ral GTPases, which are responsible for regulating exocyst complex activities.
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subcellular Location:
Cytoplasm. Cell projection > growth cone. Redistributes to growing neurites and growth cones during cell differentiation (By similarity). Binds lipids with phosphatidylinositol-3,4,5-trisphosphate groups.
Similarity:
Belongs to the EXO84 family.
Contains 1 PH domain.
Database links:Entrez Gene: 149371Human
Entrez Gene: 102058Mouse
Omim: 615283Human
SwissProt: Q8IYI6Human
SwissProt: Q6PGF7Mouse
Unigene: 356198Human
Unigene: 347360Mouse
Unigene: 392449Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.