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货号： bs-14410R-Cy5.5 基本售价： 2980.0 元 规格： 100ul
产品信息
- 产品编号
- bs-14410R-Cy5.5
- 英文名称
- Anti-DOPEY2/Cy5.5
- 中文名称
- Cy5.5标记的迟钝蛋白家族2抗体
- 别 名
- 21orf5;Dopey-2; C21orf5; DOP2_HUMAN; Dopey family member 2; DOPEY2; homolog of yeast DOP1; Protein dopey-2.
- 规格价格
- 100ul/2980元购买 大包装/询价
- 说 明 书
- 100ul
- 研究领域
- 免疫学 神经生物学 信号转导 转运蛋白
- 抗体来源
- Rabbit
- 克隆类型
- Polyclonal
- 交叉反应
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep,
- 产品应用
- ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
- 分 子 量
- 258kDa
- 性 状
- Lyophilized or Liquid
- 浓 度
- 1mg/ml
- 免 疫 原
- KLH conjugated synthetic peptide derived from human DOPEY2
- 亚 型
- IgG
- 纯化方法
- affinity purified by Protein A
- 储 存 液
- 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
- 保存条件
- Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
- 产品介绍
- background:
Dopey-2 is a 2,298 amino acid protein that is ubiquitously expressed with high levels found in the developing central nervous system where it is thought to play a role in protein trafficking between early endosomes and the late Golgi. Multiple isoforms of Dopey-2 exist due to alternative splicing events. The gene encoding Dopey-2 maps to human chromosome 21 and may be involved in the pathogenesis of Down syndrome. The smallest of the human chromosomes, chromosome 21 comprises about 1.5% of the human genome and contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimers disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukemias.
Function:
May be involved in protein traffic between late Golgi and early endosomes.
Tissue Specificity:
Ubiquitously expressed. Overexpressed in lymphoblasts from Down syndrome patients.
DISEASE:
Abundantly expressed in developing central nervous system, with highest levels in cerebellum and lowest in telencephalon.
Similarity:
Belongs to the dopey family.
Database links:Entrez Gene: 9980Human
Entrez Gene: 70028Mouse
Omim: 604803Human
SwissProt: Q9Y3R5Human
SwissProt: Q3UHQ6Mouse
Unigene: 204575Human
Unigene: 23230Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.