PC-12 nuclear extract (Forskolin stimulated)
货号：
40400 基本售价：
2465.0 元 规格：
200 ug
产品信息
概述| 货号 | 40400 |
| 使用方法 | PC-12 nuclear extract (Forskolin stimulated) is specifically recommended for studies related to 1) neuronal development, 2) neurobiology, 3) neurobiochemistry, and 4) neurotoxicity. |
性能| 供应商 | Active Motif |
| 背景 | PC-12 nuclear extract (Forskolin stimulated) was prepared from cell cultures of the rat adrenal pheochromocytoma PC-12 cell line. This cell line originated from a catecholamine-secreting tumor (pheochromocytoma) of the rat adrenal medulla. In addition to catecholamine, PC-12 cells also produce neurotransmitters. PC-12 cells are frequently used as a model system for neuronal differentiation because of their ability to differentiate into a sympathetic neuronal phenotype in response to nerve growth factor, fibroblast growth factor and, under certain conditions, epidermal growth factor.
Forskolin is a diterpene compound that activates adenylyl cyclase, thus elevating intracellular levels of cAMP. Activation of the cAMP signaling pathway is associated with the regulation of a number of cellular processes, including motility, neurite outgrowth, metabolism, transcription, and neurotransmitter secretion. Similar to nerve growth factor stimulation of the MAPK signaling pathway, forskolin stimulation leads to PKA-dependent phosphorylation and activation of the CREB transcription factor. In the brain, CREB function is primarily associated with long-term potentiation in the formation of memories. Disturbance of CREB function in the brain is linked to the progression of Huntingtons Disease and Rubinstein-Taybi syndrome, as well as some forms of cancer. |
| 运输条件 | Dry Ice |
| 存放说明 | To ensure stability, extracts should be stored at -80°C.
We recommend aliquoting the extracts into single-use fractions and then storing them at -80°C. This eliminates repeated freeze/thaw cycles. |
| 外观 | 2 x 100 µg of PC-12 nuclear extract (Forskolin stimulated) at 2.5 µg/µl. |
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