| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis
Authors: Jessica Harakal
J Immunol, 2016;197(1):27-41.
Species: Mouse
Sample Type: Whole Cells
Both rejection and tolerance of allografts can occur in the absence of secondary lymphoid tissues.
Authors: Kant C, Akiyama Y, Tanaka K, Shea S, Yamada Y, Connolly S, Marino J, Tocco G, Benichou G
J Immunol, 2015;194(3):1364-71.
Species: Mouse
Sample Type: Whole Cells
Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response.
Authors: Surls J, Nazarov-Stoica C, Kehl M, Olsen C, Casares S, Brumeanu TD
PLoS ONE, 2012;7(6):e38733.
Species: Mouse
Sample Type: Whole Cells
Antigen-specific Th9 cells exhibit uniqueness in their kinetics of cytokine production and short retention at the inflammatory site.
Authors: Tan C, Aziz MK, Lovaas JD, Vistica BP, Shi G, Wawrousek EF, Gery I
J. Immunol., 2010;185(11):6795-801.
Species: Mouse
Sample Type: Whole Cells
NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN-gamma and CXCR3 chemokines.
Authors: Wallace KL, Marshall MA, Ramos SI, Lannigan JA, Field JJ, Strieter RM, Linden J
Blood, 2009;114(3):667-76.
Species: Mouse
Sample Type: Whole Cells
T-bet inhibits both TH2 cell-mediated eosinophil recruitment and TH17 cell-mediated neutrophil recruitment into the airways.
Authors: Fujiwara M, Hirose K, Kagami S, Takatori H, Wakashin H, Tamachi T, Watanabe N, Saito Y, Iwamoto I, Nakajima H
J. Allergy Clin. Immunol., 2007;119(3):662-70.
Species: Mouse
Sample Type: Whole Cells
Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis.
Authors: De Rosa V, Procaccini C, La Cava A, Chieffi P, Nicoletti GF, Fontana S, Zappacosta S, Matarese G
J. Clin. Invest., 2006;116(2):447-55.
Species: Mouse
Sample Type: Whole Cells
TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells.
Authors: Higgins SC, Jarnicki AG, Lavelle EC, Mills KH
J. Immunol., 2006;177(11):7980-9.
Species: Mouse
Sample Type: Whole Cells
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3.
Authors: Chen, WanJun, Jin, Wenwen, Hardegen, Neil, Lei, Ke-Jian, Li, Li, Marinos, Nancy, McGrady, George, Wahl, Sharon M
J Exp Med, 2003;198(12):1875-86.
Species: Mouse
Sample Type: Whole Cells
CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production.
Authors: Thornton, A M, Shevach, E M
J Exp Med, 1998;188(2):287-96.
Species: Mouse
Sample Type: Whole Cells
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| 背景 | CD4 is a transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost, giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells, also known as T helper cells, further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th9, Th17,Th22, Tfh, and Treg cells which regulate humoral and cellular immunity. In human, CD4 is additionally expressed on macrophages, neutrophils, monocytes, NK cells, and neurons and glial cells in the brain. CD4 binds directly to MHC class II molecules on antigen presenting cells. This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a coreceptor for the gp120 surface glycoprotein of HIV-1. |
