| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Characterisation of a K390R ITK kinase dead transgenic mouse--implications for ITK as a therapeutic target.
Authors: Deakin A, Duddy G, Wilson S, Harrison S, Latcham J, Fulleylove M, Fung S, Smith J, Pedrick M, McKevitt T, Felton L, Morley J, Quint D, Fattah D, Hayes B, Gough J, Solari R
PLoS ONE, 2014;9(9):e107490.
Species: Mouse
Sample Type: Whole Cells
An artificial antigen-presenting cell with paracrine delivery of IL-2 impacts the magnitude and direction of the T cell response.
Authors: Steenblock ER, Fadel T, Labowsky M, Pober JS, Fahmy TM
J. Biol. Chem., 2011;286(40):34883-92.
Species: Mouse
Sample Type: Whole Cells
The role of glycogen synthase kinase 3 in regulating IFN-beta-mediated IL-10 production.
Authors: Wang H, Brown J, Garcia CA, Tang Y, Benakanakere MR, Greenway T, Alard P, Kinane DF, Martin M
J. Immunol., 2011;186(2):675-84.
Species: Mouse
Sample Type: Whole Cells
Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice.
Authors: Nel HJ, Hams E, Saunders SP
J. Immunol., 2011;186(8):4631-9.
Species: Mouse
Sample Type: Whole Cells
Systemic autoimmunity and defective Fas ligand secretion in the absence of the Wiskott-Aldrich syndrome protein.
Authors: Nikolov NP, Shimizu M, Cleland S
Blood, 2010;116(5):740-7.
Species: Mouse
Sample Type: Whole Cells
Functional Th1 cells are required for surgical adhesion formation in a murine model.
Authors: Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, Glimcher LH, Cruikshank WW
J. Immunol., 2008;180(10):6970-6.
Relative importance of T-cell subsets in monocytotropic ehrlichiosis: a novel effector mechanism involved in Ehrlichia-induced immunopathology in murine ehrlichiosis.
Authors: Ismail N, Crossley EC, Stevenson HL, Walker DH
Infect. Immun., 2007;75(9):4608-20.
Species: Mouse
Sample Type: Tissue Homogenates
Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function.
Authors: Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH
Blood, 2007;111(1):219-28.
Species: Mouse
Sample Type: Whole Cells
Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma.
Authors: Oniki S, Nagai H, Horikawa T, Furukawa J, Belladonna ML, Yoshimoto T, Hara I, Nishigori C
Cancer Res., 2006;66(12):6395-404.
Species: Mouse
Sample Type: Whole Cells
TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.
Authors: Kitani A, Fuss I, Pedersen A, Nawata H
J. Immunol., 2004;172(2):834-42.
Species: Mouse
Sample Type: Whole Cells
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| 背景 | CD4 is a transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost, giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells, also known as T helper cells, further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th9, Th17,Th22, Tfh, and Treg cells which regulate humoral and cellular immunity. In human, CD4 is additionally expressed on macrophages, neutrophils, monocytes, NK cells, and neurons and glial cells in the brain. CD4 binds directly to MHC class II molecules on antigen presenting cells. This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a coreceptor for the gp120 surface glycoprotein of HIV-1. |
