Recombinant KMT2D (MLL2)-SET protein
货号：
31420 基本售价：
5872.5 元 规格：
50 ug
产品信息
概述| 货号 | 31420 |
| 别名 | ALR; KMS; KMT2D; MLL4; AAD10; KABUK1; TNRC21; CAGL114 |
| 使用方法 | Recombinant MLL2-SET is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | MLL2-SET (Myeloid/lymphoid or mixed-lineage leukemia 2) is a Trithorax-group protein that function collectively to promote gene expression. MLL2 is a histone methyltransferase that methylates the Lysine 4 position of histone H3. In particular, the SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. The SET domain is responsible for its histone methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. H3K4 methylation represents a specific epigenetic tag for transcriptional activation. MLL2 is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the β-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant MLL2-SET protein was expressed in E. coli cells at a concentration of 0.4 μg/μl in 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100. |
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参考图片Recombinant MLL2-SET protein gel.
MLL2-SET protein was run on a 10% SDS-PAGE gel and stained with Coomassie blue. |
