Recombinant SUV420H2 protein
货号：
81013 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 81013 |
| 使用方法 | Recombinant SUV420H2 is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
HMT Assay Conditions: 2 µg Recombinant Nucleosomes (H3.1) (Cat. 31466) were incubated with 0 µg (-), 0.1 µg (+), 0.2 µg (++), 0.4 µg (+++) SUV420H2 protein, in 30 µl reaction containing 50 mM Tris-HCl, pH 8.6, 0.02% Triton X-100, 2 mM MgCl2, 1 mM TCEP, 50 µM SAM for 3 hr at RT. Products run on a 12.5% SDS-PAGE gel were detected with anti-H4K20me2 (Cat. 39540) or anti-H4K20me3 (Cat. 39672). SUV420H2 only was used as negative control. |
性能| 供应商 | Active Motif |
| 背景 | SUV420H2 (Suppressor Of Variegation 4-20 Homolog 2, also known as KMT5C) is a histone methyltransferase that specifically trimethylates nucleosomal histone H4 on lysine 20 (H4K20). H4K20me3 is a histone marker that represents epigenetic transcriptional repression. SUV420H2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H2 is targeted to histone H3 via its interaction with RB1 family proteins. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant SUV420H2 protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol. Please refer to product insert upon arrival for lot-specific concentration. |
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