Recombinant WTAP protein
货号：
31571 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 31571 |
| 使用方法 | Recombinant WTAP protein is suitable for use in protein-protein interaction, RNA binding assay. |
性能| 供应商 | Active Motif |
| 背景 | N6-methylated adenine (m6A) is prevalently present in nearly all RNA types and can be found in all organisms from bacteria to humans. It preferentially appears around stop codons and within long internal exons in mammalian messager RNAs. m6A plays an important role in the efficiency of mRNA splicing, processing, translation efficiency, editing and mRNA stability. m6A also takes place in other RNA molecules, such as primary miRNA (pri-miRNAs).
WTAP (Wilms Tumor 1 Associated Protein, as known as Mum2) is a ubiquitously expressed nuclear protein. WTAP is the regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation of some adenosine residues of some mRNAs. WTAP is required for accumulation of METTL3 and METTL14 to nuclear speckle. It acts as a mRNA splicing regulator. WTAP also regulates G2/M cell-cycle transition by binding to the 3’ UTR of CCNA2, which enhances its stability. WTAP can impair WT1 DNA-binding ability and inhibit expression of WT1 target genes. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant WTAP protein is supplied at a concentration of 0.2 µg/µl in 25 mM HEPES pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
