Recombinant NCOR2 (SMRT)-DAD protein
货号：
31366 基本售价：
5872.5 元 规格：
100 ug
产品信息
概述| 货号 | 31366 |
| 别名 | NCOR2; TRAC; CTG26; SMRTE; TRAC1; N-CoR2; TNRC14; TRAC-1; SMAP270; SMRTE-tau |
| 使用方法 | Recombinant SMRT-DAD is suitable for use in histone deacetylase (HDAC) assays as it is sufficient for activation of certain HDACs, including HDAC3. Use equimolar with the HDAC used in the assay. |
性能| 供应商 | Active Motif |
| 背景 | SMRT, also known as NCOR2, is a transcriptional corepressor that associates with a subset of nuclear receptors including RAR, PR, GR and TR in the absence of ligand. It is part of a large co-repressor protein complex that includes SIN3A/B and histone deacetylases HDAC1 and HDAC2. The deacetylase activating domain (DAD) functions to bind and activate histone deacetylase 3 (HDAC3) and is also required for N-CoR interaction with HDAC3 and its corepressor activity. SMRT and N-CoR mediated transcriptional corepression plays a significant role in development and metabolism and aberrant corepressor activity is associated with the pathogenesis of myeloid leukemias. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | 100 µg of recombinant SMRT-DAD protein expressed in E. coli at a concentration of 0.49 mg/ml in 50 mM Tris pH 8.0, 150 mM NaCl, 1mM DTT and 50% glycerol. |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
参考图片SMRT-DAD protein gel.
SMRT-DAD run on an SDS-PAGE gel and stained with Coomassie blue. |
