Recombinant SIRT4 (25-314) protein
货号：
31530 基本售价：
5872.5 元 规格：
50 ug
产品信息
概述| 货号 | 31530 |
| 别名 | SIRT-4, Sirtuin 4, EC 3.5.1, SIR2L4, SIR2-Like 4 |
| 使用方法 | Recombinant SIRT4 protein is useful for protein deacetylase, lipoamidase and ADP-ribosyl transferase assays and the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | SIRT4 (Sirtuin 4) is a member of the SIR2 / Sirtuin family of NAD+-dependant deacetylase enzymes. Sirtuin family enzymes can be found in the cytoplasm, mitochondria or nucleus of a cell and are ubiquitously expressed. SIRT4 has multiple enzymatic functions, such as NAD+-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. SIRT4 catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. It inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. SIRT4 catalyzes the transfer of ADP-ribosyl groups onto target proteins, such as mitochondrial GLUD1. It acts as a negative regulator of mitochondrial glutamine metabolism by mediating mono ADP-ribosylation of GLUD1. It also acts as a NAD+-dependent protein deacetylase to mediate deacetylation of Lys-471 of MLYCD, inhibiting its activity, thereby acting as a regulator of lipid homeostasis. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant SIRT4 (25-314) protein is supplied in 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol. Please refer to product insert upon arrival for lot-specific concentration. |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
