Recombinant HDAC7 (518-991) protein
货号：
31535 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 31535 |
| 别名 | Histone Deacetylase 7, HD7; HD7A; HDAC7A |
| 使用方法 | Recombinant HDAC7 (518-991) protein is useful for the study of enzyme kinetics, and chromatin regulation during transcription. |
性能| 供应商 | Active Motif |
| 背景 | HDAC7 (Histone Deacetylase 7) is a member of the class IIa mammalian histone deacetylases (HDACs) involved in regulating chromatin structure during transcription. These enzymes catalyze the removal of acetyl groups from lysine residues of histones and other cellular proteins. Lysine N-ε-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in regulation of gene expression in various cellular functions. It consists of the transfer of an acetyl moiety from an acetyl coenzyme A to the ε-amino group of a lysine residue.
In vivo, acetylation is controlled by the antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The HDACs are grouped into four classes, on the basis of similarity to yeast counterparts: HDAC class I (HDAC1, HDAC2, HDAC3 and HDAC8), class II (HDAC4, HDAC5, HDAC6, HDAC7, 9 and 10), class III (SIRT1-7) and class IV (HDAC11).
HDAC7 is Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). HDAC7 may be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. HDAC7 positively regulates the transcriptional repressor activity of FOXP3. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant HDAC7 (518-991) protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration. |
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