Recombinant OGT protein
货号：
31524 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 31524 |
| 别名 | O-linked N-Acetylglucosamine Transferase, GlcNAc, EC 2.4.1.186 HINCUT-1, O-GLCNAC, HRNT1 |
| 使用方法 | Recombinant OGT protein is useful for the study of protein-protein interaction, enzyme kinetics, screening inhibitors, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | OGT (O-linked N-acetylglucosamine (GlcNAc) transferase) catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to serine or threonine residues in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). OGT can glycosylate a large and diverse number of proteins including HCF1, AKT1, MLL5 and histone H2B. It can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Specifically OGT has been shown to interact directly with TET2 and TET3, enzymes that catalyze the oxidation of 5-methylcytosine on DNA. The TET/OGT interaction leads to GlcNAcetylation of HCF1, a protein component of the COMPASS complex, which regulates H3K4 methylation and gene expression. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant full length Mouse OGT protein is supplied in 25 mM HEPES pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. Please refer to product insert upon arrival for lot-specific concentration. |
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