Recombinant USP7 protein
货号：
31525 基本售价：
5872.5 元 规格：
20 ug
产品信息
概述| 货号 | 31525 |
| 别名 | Ubiquitin Specific Peptidase 7, Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated) |
| 使用方法 | This protein is useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
性能| 供应商 | Active Motif |
| 背景 | USP7 (Ubiquitin Specific Peptidase 7 (Herpes Virus-Associated)) belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. USP7 de-ubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, UHRF1, PTEN and DAXX. Together with DAXX, USP7 prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. USP7 de-ubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. USP7 also de-ubiquitinates FOXO4 and inhibits FOXO4-induced transcriptional activity. Together with DAXX, USP7 is involved in the de-ubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. USP7 de-ubiquitinates UHRF1, which prevents its degradation and promoting DNA methylation by DNMT1. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant full length USP7 protein is supplied in 25 mM Tris-HCl pH 8.0, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100. Please refer to product insert upon arrival for lot-specific concentration. |
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