Recombinant Histone H3K27me3 (MLA)
货号：
31579 基本售价：
3625.0 元 规格：
100 ug
产品信息
概述| 货号 | 31579 |
| 别名 | Histone H3, H3, MLA |
| 使用方法 | Recombinant histones are suitable for use as positive controls in the analysis of histone post- translational modifiations, as substrates for histone modifiation enzymes, or to generate chromatin in vitro. |
性能| 供应商 | Active Motif |
| 背景 | Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 146 base pairs of DNA wrapped around an octamer of core histone proteins (two each of H2A, H2B, H3 and H4). Histone H1 is a linker protein, present at the interface between the nucleosome core and DNA entry/exit points.
Recombinant Histone H3K27me3 (MLA) has been generated using the patented Methylated Lysine Analog (MLA) technology. In MLA, methylated histones are generated via a chemical alkylation reaction that substitutes a methylated analog of lysine, aminoethylcysteine, for the existing lysine at the desired residue. Aminoethylcysteine is structurally and chemically similar to lysine, though it contains a sulfide substitution in place of the lysine Υ-methylene. The MLA technique provides precise control over the site and degree of methylation. The MLA technology is covered under U.S. Patent No. 8,278,112. |
| 运输条件 | Dry Ice |
| 存放说明 | Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation. Avoid repeated freeze/thaw cycles and keep on ice when not in storage. |
| 外观 | Recombinant Histone H3K27me3 (MLA) is supplied in 50 mM Tris-HCl, pH 8.0, 150 mM NaCl and 5% glycerol. Please refer to product insert upon arrival for lot-specific concentration. |
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