| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Cudraflavone C Induces Apoptosis of A375.S2 Melanoma Cells through Mitochondrial ROS Production and MAPK Activation
Authors: CW Lee, FL Yen, HH Ko, SY Li, YC Chiang, MH Lee, MH Tsai, LF Hsu
Int J Mol Sci, 2017;18(7):. 2017
Bufalin sensitizes human bladder carcinoma cells to TRAIL-mediated apoptosis
Authors: KH Kang, MH Han, JW Jeong, C Park, SH Lee, HW Lee, SH Hong, YH Choi, SH Hong
Oncol Lett, 2017;14(1):853-859. 2017
Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic ?-Cells
Authors: AMTA Nahdi, A John, H Raza
Oxid Med Cell Longev, 2017;2017(0):7054272. 2017
In vitro assessment of anti-proliferative effect induced by ?-mangostin from Cratoxylum arborescens on HeLa cells
Authors: AI El Habbash, N Mohd Hashi, MY Ibrahim, M Yahayu, FAE Omer, M Abd Rahman, N Nordin, GEC Lian
PeerJ, 2017;5(0):e3460. 2017
Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway
Authors: M Lin, S Tang, C Zhang, H Chen, W Huang, Y Liu, J Zhang
Acta Pharm Sin B, 2017;7(1):59-64. 2017
The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission
J Cell Mol Med, 2016;0(0):. 2016
Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
Authors: C Xue, Y Chen, DN Hu, C Iacob, C Lu, Z Huang
Oncol Lett, 2016;12(6):4813-4820. 2016
Augmented efficacy with the combination of blockade of the Notch-1 pathway, bortezomib and romidepsin in a murine MT-1 adult T-cell leukemia model.
Authors: Yu P, Petrus M, Ju W, Zhang M, Conlon K, Nakagawa M, Maeda M, Bamford R, Waldmann T
Leukemia, 2015;29(3):556-66. 2015
Decidualization and syndecan-1 knock down sensitize endometrial stromal cells to apoptosis induced by embryonic stimuli.
Authors: Boeddeker S, Baston-Buest D, Fehm T, Kruessel J, Hess A
PLoS ONE, 2015;10(4):e0121103. 2015
Protective effect of Aframomum melegueta phenolics against CCl(4)-induced rat hepatocytes damage; role of apoptosis and pro-inflammatory cytokines inhibition.
Authors: El-Halawany A, El Dine R, El Sayed N, Hattori M
Sci Rep, 2014;4(0):5880. 2014
Malignant melanoma cells acquire resistance to DNA interstrand cross-linking chemotherapeutics by p53-triggered upregulation of DDB2/XPC-mediated DNA repair.
Authors: Barckhausen C, Roos W, Naumann S, Kaina B
Oncogene, 2014;33(15):1964-74. 2014
Curcumin-loaded nanoparticles enhance apoptotic cell death of U2OS human osteosarcoma cells through the Akt-Bad signaling pathway.
Authors: Peng S, Lee C, Hour M, Tsai S, Kuo D, Chen F, Shieh P, Yang J
Int J Oncol, 2014;44(1):238-46. 2014
Upregulation of miR-18a-5p contributes to epidermal necrolysis in severe drug eruptions.
Authors: Ichihara A, Wang Z, Jinnin M, Izuno Y, Shimozono N, Yamane K, Fujisawa A, Moriya C, Fukushima S, Inoue Y, Ihn H
J Allergy Clin Immunol, 2014;133(4):1065-74. 2014
Soy soluble polysaccharide induces apoptosis in HCT116 human colon cancer cells via reactive oxygen species generation.
Authors: Ko Y, Jeong J, Choi Y, Ryu C
Mol Med Rep, 2013;8(6):1767-72. 2013
Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis.
Authors: Han B, You B, Park W
Oncol Rep, 2013;30(6):2999-3005. 2013
Combination of albendazole and 2-methoxyestradiol significantly improves the survival of HCT-116 tumor-bearing nude mice.
Authors: Ehteda, Anahid, Galettis, Peter, Pillai, Krishna, Morris, David L
BMC Cancer, 2013;13(0):86. 2013
The novel carboxamide analog ITR-284 induces caspase-dependent apoptotic cell death in human hepatocellular and colorectal cancer cells.
Authors: Liao Y, Lu C, Lai K, Yang J, Kuo S, Wen Y, Fushiya S, Wu T
Mol Med Rep, 2013;7(5):1539-44. 2013
Citrus aurantium L. exhibits apoptotic effects on U937 human leukemia cells partly through inhibition of Akt.
Authors: Han MH, Lee WS, Lu JN
Int. J. Oncol., 2012;40(6):2090-6. 2012
Antimitochondrial autoantibodies in pemphigus vulgaris: a missing link in disease pathophysiology.
Authors: Marchenko S, Chernyavsky AI, Arredondo J, Gindi V, Grando SA
J. Biol. Chem., 2010;285(6):3695-704. 2010
A proteomic approach to the identification of molecular targets in subsequent apoptosis of HEL cells after diosgenin-induced megakaryocytic differentiation.
Authors: Cailleteau C, Liagre B, Beneytout JL
J. Cell. Biochem., 2009;107(4):785-96. 2009
Effective treatment of a murine model of adult T-cell leukemia using depsipeptide and its combination with unmodified daclizumab directed toward CD25.
Authors: Chen J, Zhang M, Ju W, Waldmann TA
Blood, 2009;113(6):1287-93. 2009
EphB4 provides survival advantage to squamous cell carcinoma of the head and neck.
Authors: Masood R, Kumar SR, Sinha UK, Crowe DL, Krasnoperov V, Reddy RK, Zozulya S, Singh J, Xia G, Broek D, Schonthal AH, Gill PS
Int. J. Cancer, 2006;119(6):1236-48. 2006
Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin.
Authors: Tsai WS, Yeow WS, Chua A, Reddy RM, Nguyen DM, Schrump DS
Mol. Cancer Ther., 2006;5(12):2977-90. 2006
Cardiomyocyte-specific Bcl-2 overexpression attenuates ischemia-reperfusion injury, immune response during acute rejection, and graft coronary artery disease.
Authors: Tanaka M, Nakae S, Terry RD, Mokhtari GK, Gunawan F, Balsam LB, Kaneda H, Kofidis T, Tsao PS, Robbins RC
Blood, 2004;104(12):3789-96. 2004
Suppression of graft coronary artery disease by a brief treatment with a selective epsilonPKC activator and a deltaPKC inhibitor in murine cardiac allografts.
Authors: Tanaka M, Terry RD, Mokhtari GK, Inagaki K, Koyanagi T, Kofidis T, Mochly-Rosen D, Robbins RC
Circulation, 2004;110(11):II194-9. 2004
Apaf-1 is a mediator of E2F-1-induced apoptosis.
Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
J. Biol. Chem., 2002;277(42):39760-8. 2002
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| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
