| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Artonin E induces p53-independent G1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cells
Authors: IC Etti, A Rasedee, NM Hashim, AB Abdul, A Kadir, SK Yeap, P Waziri, I Malami, KL Lim, CJ Etti
Drug Des Devel Ther, 2017;11(0):865-879. 2017
Sulforaphane sensitizes human breast cancer cells to paclitaxel-induced apoptosis by downregulating the NF-?B signaling pathway
Authors: SH Kim, HJ Park, DO Moon
Oncol Lett, 2017;13(6):4427-4432. 2017
Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids
Authors: FJ Martínez-R, J Pérez-Lasp, ME Santiago-G, AG Alemán-Rey, E García-San, Y Rodríguez-, C Calo-Guada, I Otero-Pagá, RN Ayala-Pagá, M Martínez, YM Cantres-Ro, LM Meléndez, JL Barreto-Es
PLoS ONE, 2017;12(7):e0180409. 2017
The molecular mechanism of the anticancer effect of Artonin E in MDA-MB 231 triple negative breast cancer cells
Authors: IC Etti, R Abdullah, A Kadir, NM Hashim, SK Yeap, MU Imam, F Ramli, I Malami, KL Lam, U Etti, P Waziri, M Rahman
PLoS ONE, 2017;12(8):e0182357. 2017
Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway
PLoS ONE, 2016;11(5):e0154023. 2016
A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
Authors: Chiang, Nai-Jung, Lin, Ching-I, Liou, Jing-Pin, Kuo, Ching-Ch, Chang, Chi-Yen, Chen, Li-Tzong, Chang, Jang-Yan
PLoS ONE, 2013;8(3):e58953. 2013
Rapid and profound potentiation of Apo2L/TRAIL-mediated cytotoxicity and apoptosis in thoracic cancer cells by the histone deacetylase inhibitor Trichostatin A: the essential role of the mitochondria-mediated caspase activation cascade.
Authors: Reddy RM, Yeow WS, Chua A, Nguyen DM, Baras A, Ziauddin MF, Shamimi-Noori SM, Maxhimer JB, Schrump DS
Apoptosis, 2007;12(1):55-71. 2007
Diclofenac, a non-steroidal anti-inflammatory drug, suppresses apoptosis induced by endoplasmic reticulum stresses by inhibiting caspase signaling.
Authors: Yamazaki T, Muramoto M, Oe T, Morikawa N, Okitsu O, Nagashima T, Nishimura S, Katayama Y, Kita Y
Neuropharmacology, 2006;50(5):558-67. 2006
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
Authors: Su YT, Chang HL, Shyue SK, Hsu SL
Biochem. Pharmacol., 2005;70(2):229-41. 2005
Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo.
Authors: Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ
Cancer Lett., 2005;222(2):183-93. 2005
Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells.
Authors: Sordillo LM, Weaver JA, Cao YZ, Corl C, Sylte MJ, Mullarky IK
Prostaglandins Other Lipid Mediat., 2005;76(1):19-34. 2005
Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.
Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
Cardiovasc. Res., 2004;61(1):143-51. 2004
Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway.
Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
Cardiovasc. Res., 2004;62(3):558-67. 2004
IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
Authors: Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, Chen WS, Yang WK
J. Interferon Cytokine Res., 2004;24(4):231-43. 2004
IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
Authors: Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, Chen WS, Yang WK
J. Interferon Cytokine Res., 2004;24(4):231-43. 2004
Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways.
Authors: Walford GA, Moussignac RL, Scribner AW, Loscalzo J, Leopold JA
J. Biol. Chem., 2003;279(6):4425-32. 2003
The mitochondria-regulated death pathway mediates asbestos-induced alveolar epithelial cell apoptosis.
Authors: Panduri V, Weitzman SA, Chandel N, Kamp DW
Am. J. Respir. Cell Mol. Biol., 2003;28(2):241-8. 2003
Ultraviolet light-induced apoptotic death is impaired by the HMG-CoA reductase inhibitor lovastatin.
Authors: Bardeleben R, Kaina B, Fritz G
Biochem. Biophys. Res. Commun., 2003;307(2):401-7. 2003
Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard.
Authors: Becker R, Ritter A, Eichhorn U, Lips J, Bertram B, Wiessler M, Zdzienicka MZ, Kaina B
Br. J. Cancer, 2002;86(1):130-5. 2002
Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs.
Authors: Zhang Y, Chong E, Herman B
Exp. Gerontol., 2002;37(6):777-89. 2002
Caspases as key executors of methyl selenium-induced apoptosis (anoikis) of DU-145 prostate cancer cells.
Authors: Jiang C, Wang Z, Ganther H, Lu J
Cancer Res., 2001;61(7):3062-70. 2001
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| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
