| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Sulforaphane sensitizes human breast cancer cells to paclitaxel-induced apoptosis by downregulating the NF-?B signaling pathway
Authors: SH Kim, HJ Park, DO Moon
Oncol Lett, 2017;13(6):4427-4432. 2017
miR-495 sensitizes MDR cancer cells to the combination of doxorubicin and taxol by inhibiting MDR1 expression
Authors: Z Zou, R Zou, D Zong, Y Shi, J Chen, J Huang, J Zhu, L Chen, X Bao, Y Liu, W Liu, W Huang, J Hu, Z Chen, X Lao, C Chen, X Huang, Y Lu, X Ni, D Fang, D Wu, S Lu, M Jiang, C Qiu, Y Wu, Q Qiu, Y Dong, Y Su, C Zhao, Z Zhong, J Cai, Y Liang
J. Cell. Mol. Med., 2017;0(0):. 2017
Endothelial cell colony forming units derived from malignant breast diseases are resistant to tumor necrosis factor-?-induced apoptosis
Sci Rep, 2016;6(0):37450. 2016
Pemetrexed induces S-phase arrest and apoptosis via a deregulated activation of Akt signaling pathway.
Authors: Chen K, Yang T, Wu C, Cheng C, Hsu S, Hung H, Chen J, Chang G
PLoS ONE, 2014;9(5):e97888. 2014
MUC16 mucin (CA125) attenuates TRAIL-induced apoptosis by decreasing TRAIL receptor R2 expression and increasing c-FLIP expression.
Authors: Matte I, Lane D, Boivin M, Rancourt C, Piche A
BMC Cancer, 2014;14(0):234. 2014
MCL-1ES induces MCL-1L-dependent BAX- and BAK-independent mitochondrial apoptosis.
Authors: Kim, Jae-Hong, Bae, Jeehyeon
PLoS ONE, 2013;8(11):e79626. 2013
Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis.
Authors: Zou, Lin, Feng, Yan, Li, Yan, Zhang, Ming, Chen, Chan, Cai, Jiayan, Gong, Yu, Wang, Larry, Thurman, Joshua M, Wu, Xiaobo, Atkinson, John P, Chao, Wei
J Immunol, 2013;191(11):5625-35. 2013
A novel synthetic microtubule inhibitor, MPT0B214 exhibits antitumor activity in human tumor cells through mitochondria-dependent intrinsic pathway.
Authors: Chiang, Nai-Jung, Lin, Ching-I, Liou, Jing-Pin, Kuo, Ching-Ch, Chang, Chi-Yen, Chen, Li-Tzong, Chang, Jang-Yan
PLoS ONE, 2013;8(3):e58953. 2013
Cytoplasmic redistribution and cleavage of AUF1 during coxsackievirus infection enhance the stability of its viral genome.
Authors: Wong, Jerry, Si, Xiaoning, Angeles, Arkhjami, Zhang, Jingchun, Shi, Junyan, Fung, Gabriel, Jagdeo, Julienne, Wang, Tianying, Zhong, Zhaohua, Jan, Eric, Luo, Honglin
FASEB J, 2013;27(7):2777-87. 2013
Tumor cells expressing a fusion protein of MULT1 and Fas are rejected in vivo by apoptosis and NK cell activation.
Authors: Kotturi HS, Li J, Branham-OConnor M, Stickel SL, Yu X, Wagner TE, Wei Y
Gene Ther., 2008;15(19):1302-10. 2008
Enhanced 15-HPETE production during oxidant stress induces apoptosis of endothelial cells.
Authors: Sordillo LM, Weaver JA, Cao YZ, Corl C, Sylte MJ, Mullarky IK
Prostaglandins Other Lipid Mediat., 2005;76(1):19-34. 2005
Anti-proliferative activity of Bupleurum scrozonerifolium in A549 human lung cancer cells in vitro and in vivo.
Authors: Cheng YL, Lee SC, Lin SZ, Chang WL, Chen YL, Tsai NM, Liu YC, Tzao C, Yu DS, Harn HJ
Cancer Lett., 2005;222(2):183-93. 2005
Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway.
Authors: Su YT, Chang HL, Shyue SK, Hsu SL
Biochem. Pharmacol., 2005;70(2):229-41. 2005
Norepinephrine induces apoptosis in neonatal rat endothelial cells via down-regulation of Bcl-2 and activation of beta-adrenergic and caspase-2 pathways.
Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
Cardiovasc. Res., 2004;61(1):143-51. 2004
IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
Authors: Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, Chen WS, Yang WK
J. Interferon Cytokine Res., 2004;24(4):231-43. 2004
Norepinephrine induces apoptosis in neonatal rat cardiomyocytes through a reactive oxygen species-TNF alpha-caspase signaling pathway.
Authors: Fu YC, Chi CS, Yin SC, Hwang B, Chiu YT, Hsu SL
Cardiovasc. Res., 2004;62(3):558-67. 2004
IFN-beta induces caspase-mediated apoptosis by disrupting mitochondria in human advanced stage colon cancer cell lines.
Authors: Juang SH, Wei SJ, Hung YM, Hsu CY, Yang DM, Liu KJ, Chen WS, Yang WK
J. Interferon Cytokine Res., 2004;24(4):231-43. 2004
Age-associated increases in the activity of multiple caspases in Fisher 344 rat organs.
Authors: Zhang Y, Chong E, Herman B
Exp. Gerontol., 2002;37(6):777-89. 2002
Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug beta-D-glucosyl-ifosfamide mustard.
Authors: Becker R, Ritter A, Eichhorn U, Lips J, Bertram B, Wiessler M, Zdzienicka MZ, Kaina B
Br. J. Cancer, 2002;86(1):130-5. 2002
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| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
