| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
Authors: O Arizmendi, WD Picking, WL Picking
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
The Topoisomerase 1 Inhibitor Austrobailignan-1 Isolated from Koelreuteria henryi Induces a G2/M-Phase Arrest and Cell Death Independently of p53 in Non-Small Cell Lung Cancer Cells.
Authors: Wu C, Huang K, Yang T, Li Y, Wen C, Hsu S, Chen T
PLoS ONE, 2015;10(7):e0132052.
Caspase-2 maintains bone homeostasis by inducing apoptosis of oxidatively-damaged osteoclasts.
Authors: Sharma, Ramaswam, Callaway, Danielle, Vanegas, Difernan, Bendele, Michelle, Lopez-Cruzan, Marisa, Horn, Diane, Guda, Teja, Fajardo, Roberto, Abboud-Werner, Sherry, Herman, Brian
PLoS ONE, 2014;9(4):e93696.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
Cancer Cell Int, 2013;13(1):105.
Species: Human
Sample Type: Whole Cells
Association of a single dose of gonadotropin-releasing hormone antagonist with nitric oxide and embryo quality in in vitro fertilization cycles.
Authors: Lee TH, Wu MY, Chen HF, Chen SU, Ho HN, Yang YS
Fertil. Steril., 2006;86(4):1020-2.
Species: Human
Sample Type: Follicular Fluid
Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.
Authors: Cao Y, Adhikari S, Ang AD, Moore PK, Bhatia M
Am. J. Physiol., Cell Physiol., 2006;291(3):C503-10.
Species: Mouse
Sample Type: Cell Culture Supernates
Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.
Authors: Shah N, Asch RJ, Lysholm AS, Lebien TW
Blood, 2004;104(9):2873-8.
Species: Human
Sample Type: Whole Cells
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| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
