| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
Authors: O Arizmendi, WD Picking, WL Picking
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro
Sci Rep, 2016;6(0):26277.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.
Authors: Cheung S, Chuang P, Huang H, Hwang-Verslues W, Cho C, Yang W, Shen C, Hsiao M, Hsu T, Chang C, Wong C
Proc Natl Acad Sci U S A, 2016;113(4):960-5.
Species: Human
Sample Type: Whole Cells
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708.
Species: Human
Sample Type: Whole Cells
Mesenchymal Wnt/beta-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10.
Authors: Yang Z, Balic A, Michon F, Juuri E, Thesleff I
Stem Cells, 2015;33(5):1670-81.
Species: Mouse
Sample Type: Whole Tissue
Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.
Authors: Oskarsson M, Singh K, Wang J, Vlodavsky I, Li J, Westermark G
J Biol Chem, 2015;290(24):15121-32.
Species: Hamster
Sample Type: Whole Cells
Application: Bioassay
Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
Authors: You B, Park W
Int J Oncol, 2014;44(5):1745-55.
Species: Human
Sample Type: Whole Cells
PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
Authors: You B, Shin H, Park W
Int J Oncol, 2014;44(1):301-8.
Species: Human
Sample Type: Whole Cells
Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells.
Authors: Ham S, Kim K, Kwon T, Bak Y, Lee D, Song Y, Park S, Park Y, Kim M, Kang J, Hong J, Yoon D
Oncol Rep, 2014;31(6):2683-91.
Species: Human
Sample Type: Whole Cells
Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development.
Authors: Lin J, Lin S, Chen W, Yen Y, Lai C, Tao M, Lin Y, Miaw S, Wu-Hsieh B
J Immunol, 2014;193(3):1258-67.
Species: Human
Sample Type: Whole Cells
Inhibition of cancer cell proliferation and apoptosis-inducing activity of fungal taxol and its precursor baccatin III purified from endophytic Fusarium solani.
Authors: Chakravarthi B, Sujay R, Kuriakose G, Karande A, Jayabaskaran C
Cancer Cell Int, 2013;13(1):105.
Species: Human
Sample Type: Whole Cells
PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Authors: Shin H, You B, Park W
Oncol Lett, 2013;6(6):1804-1810.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells.
Authors: Bauer G
Anticancer Res, 2013;33(9):3589-602.
Species: Human
Sample Type: Whole Cells
Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
Elife, 2013;2(0):e00999.
Species: Drosophila
Sample Type: Whole Cells
Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
Authors: Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S
Int J Oncol, 2013;42(2):525-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Combination of RGD compound and low-dose paclitaxel induces apoptosis in human glioblastoma cells.
Authors: Chang MW, Lo JM, Juan HF, Chang HY, Chuang CY
PLoS ONE, 2012;7(5):e37935.
Species: Human
Sample Type: Whole Cells
Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
Authors: Liang X, Moseman EA, Farrar MA
Blood, 2010;115(24):5041-52.
Species: Human
Sample Type: Whole Cells
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Authors: Lee SC, Chan J, Clement MV, Pervaiz S
Proteomics, 2006;6(8):2386-94.
Species: Human
Sample Type: Cell Lysates
Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.
Authors: Cao Y, Adhikari S, Ang AD, Moore PK, Bhatia M
Am. J. Physiol., Cell Physiol., 2006;291(3):C503-10.
Species: Mouse
Sample Type: Cell Culture Supernates
Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases.
Authors: Conde de la Rosa L, Schoemaker MH, Vrenken TE, Buist-Homan M, Havinga R, Jansen PL, Moshage H
J. Hepatol., 2006;44(5):918-29.
Species: Human
Sample Type: Whole Cells
Enhancement of Apo2L/TRAIL-mediated cytotoxicity in esophageal cancer cells by cisplatin.
Authors: Tsai WS, Yeow WS, Chua A, Reddy RM, Nguyen DM, Schrump DS
Mol. Cancer Ther., 2006;5(12):2977-90.
Species: Human
Sample Type: Whole Cells
Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor.
Authors: Shah N, Asch RJ, Lysholm AS, Lebien TW
Blood, 2004;104(9):2873-8.
Species: Human
Sample Type: Whole Cells
Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).
Authors: Chopin V, Slomianny C, Hondermarck H, Le Bourhis X
Exp. Cell Res., 2004;298(2):560-73.
Species: Human
Sample Type: Cell Lysates
Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Authors: Attali G, Gancz D, Fishelson Z
Eur. J. Immunol., 2004;34(11):3236-45.
Species: Human
Sample Type: Whole Cells
RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood, 2004;103(11):4180-7.
Species: Human
Sample Type: Whole Cells
Study of caspase inhibitors for limiting death in mammalian cell culture.
Authors: Sauerwald TM, Oyler GA, Betenbaugh MJ
Biotechnol. Bioeng., 2003;81(3):329-40.
Species: Human
Sample Type: Whole Cells
Apaf-1 is a mediator of E2F-1-induced apoptosis.
Authors: Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, Yamada H, Matsuda M, Kano Y, Nakamura M
J. Biol. Chem., 2002;277(42):39760-8.
Species: Human
Sample Type: Whole Cells
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| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
