| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Lipopolysaccharide (LPS) Promotes Apoptosis in Human Breast Epithelial x Breast Cancer Hybrids, but Not in Parental Cells.
Authors: Fried S, Tosun S, Troost G, Keil S, Zaenker K, Dittmar T
PLoS ONE, 2016;11(2):e0148438.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Stage-specific embryonic antigen-3 (SSEA-3) and beta3GalT5 are cancer specific and significant markers for breast cancer stem cells.
Authors: Cheung S, Chuang P, Huang H, Hwang-Verslues W, Cho C, Yang W, Shen C, Hsiao M, Hsu T, Chang C, Wong C
Proc Natl Acad Sci U S A, 2016;113(4):960-5.
Species: Human
Sample Type: Whole Cells
The Role of Prostate Apoptosis Response-4 (Par-4) in Mycobacterium tuberculosis Infected Macrophages
Sci Rep, 2016;6(0):32079.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Heterogeneous Nuclear Ribonucleoprotein L is required for the survival and functional integrity of murine hematopoietic stem cells
Authors: Marie-Claude Gaudreau
Sci Rep, 2016;6(0):27379.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro
Sci Rep, 2016;6(0):26277.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Macrophage Apoptosis Triggered by IpaD from Shigella flexneri
Authors: O Arizmendi, WD Picking, WL Picking
Infect Immun, 2016;0(0):.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Caspase-8 as an Effector and Regulator of NLRP3 Inflammasome Signaling.
Authors: Antonopoulos C, Russo H, El Sanadi C, Martin B, Li X, Kaiser W, Mocarski E, Dubyak G
J Biol Chem, 2015;290(33):20167-84.
Species: Mouse
Sample Type: Whole Cells
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
Authors: Gonzalez-Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, Dube P, Bergman M, Orihuela C
PLoS Pathog, 2015;11(12):e1005337.
Species: Mouse
Sample Type: Whole Cells
Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis.
Authors: Oskarsson M, Singh K, Wang J, Vlodavsky I, Li J, Westermark G
J Biol Chem, 2015;290(24):15121-32.
Species: Hamster
Sample Type: Whole Cells
Application: Bioassay
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708.
Species: Human
Sample Type: Whole Cells
PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis.
Authors: You B, Shin H, Park W
Int J Oncol, 2014;44(1):301-8.
Species: Human
Sample Type: Whole Cells
Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels.
Authors: You B, Park W
Int J Oncol, 2014;44(5):1745-55.
Species: Human
Sample Type: Whole Cells
Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells.
Authors: Kang M, Kim I, Nam T
Oncol Rep, 2014;32(4):1341-6.
Species: Human
Sample Type: Whole Cells
Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development.
Authors: Lin J, Lin S, Chen W, Yen Y, Lai C, Tao M, Lin Y, Miaw S, Wu-Hsieh B
J Immunol, 2014;193(3):1258-67.
Species: Human
Sample Type: Whole Cells
Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells.
Authors: Ham S, Kim K, Kwon T, Bak Y, Lee D, Song Y, Park S, Park Y, Kim M, Kang J, Hong J, Yoon D
Oncol Rep, 2014;31(6):2683-91.
Species: Human
Sample Type: Whole Cells
NLRP3 inflammasome activation by Paracoccidioides brasiliensis.
Authors: Tavares A, Magalhaes K, Almeida R, Correa R, Burgel P, Bocca A
PLoS Negl Trop Dis, 2013;7(12):e2595.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
TAK1 is essential for osteoclast differentiation and is an important modulator of cell death by apoptosis and necroptosis.
Authors: Lamothe B, Lai Y, Xie M, Schneider M, Darnay B
Mol Cell Biol, 2013;33(3):582-95.
Species: Mouse
Sample Type: Whole Cells
PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion.
Authors: Shin H, You B, Park W
Oncol Lett, 2013;6(6):1804-1810.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Zoledronic acid significantly enhances radiationinduced apoptosis against human fibrosarcoma cells by inhibiting radioadaptive signaling.
Authors: Koto K, Murata H, Kimura S, Sawai Y, Horie N, Matsui T, Ryu K, Ashihara E, Maekawa T, Kubo T, Fushiki S
Int J Oncol, 2013;42(2):525-34.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells.
Authors: Bauer G
Anticancer Res, 2013;33(9):3589-602.
Species: Human
Sample Type: Whole Cells
Brahma is essential for Drosophila intestinal stem cell proliferation and regulated by Hippo signaling.
Authors: Jin, Yunyun, Xu, Jinjin, Yin, Meng-Xin, Lu, Yi, Hu, Lianxin, Li, Peixue, Zhang, Peng, Yuan, Zengqian, Ho, Margaret, Ji, Hongbin, Zhao, Yun, Zhang, Lei
Elife, 2013;2(0):e00999.
Species: Drosophila
Sample Type: Whole Cells
Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response.
Authors: Kang Z, Chen J, Yu Y, Li B, Sun S, Zhang B, Cao L
Clin Cancer Res, 2011;17(10):3181-92.
Species: Human
Sample Type: Whole Cells
Astrocyte and muscle-derived secreted factors differentially regulate motoneuron survival.
Authors: Taylor AR, Gifondorwa DJ, Newbern JM, Robinson MB, Strupe JL, Prevette D, Oppenheim RW, Milligan CE
J. Neurosci., 2007;27(3):634-44.
Species: Chicken
Sample Type: Whole Cells
Acquired resistance to TRAIL-induced apoptosis in human ovarian cancer cells is conferred by increased turnover of mature caspase-3.
Authors: Lane D, Cote M, Grondin R, Couture MC, Piche A
Mol. Cancer Ther., 2006;5(3):509-21.
Species: Human
Sample Type: Whole Cells
Application: Bioassay
Protective effects of neurotrophic factors on tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis of murine adrenal chromaffin cell line tsAM5D.
Authors: Murata T, Tsuboi M, Hikita K, Kaneda N
J. Biol. Chem., 2006;281(32):22503-16.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide.
Authors: Cao Y, Adhikari S, Ang AD, Moore PK, Bhatia M
Am. J. Physiol., Cell Physiol., 2006;291(3):C503-10.
Species: Mouse
Sample Type: Cell Culture Supernates
Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop.
Authors: Lee SC, Chan J, Clement MV, Pervaiz S
Proteomics, 2006;6(8):2386-94.
Species: Human
Sample Type: Cell Lysates
HIV-1 tat protein and cell proliferation and survival: a brief review.
Authors: Gibellini D, Vitone F, Schiavone P, Re MC
New Microbiol., 2005;28(2):95-109.
Species: Human
Sample Type: Whole Cells
Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1).
Authors: Chopin V, Slomianny C, Hondermarck H, Le Bourhis X
Exp. Cell Res., 2004;298(2):560-73.
Species: Human
Sample Type: Cell Lysates
RGDS peptide induces caspase 8 and caspase 9 activation in human endothelial cells.
Authors: Aguzzi MS, Giampietri C, De Marchis F, Padula F, Gaeta R, Ragone G, Capogrossi MC, Facchiano A
Blood, 2004;103(11):4180-7.
Species: Human
Sample Type: Whole Cells
Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Authors: Attali G, Gancz D, Fishelson Z
Eur. J. Immunol., 2004;34(11):3236-45.
Species: Human
Sample Type: Whole Cells
Study of caspase inhibitors for limiting death in mammalian cell culture.
Authors: Sauerwald TM, Oyler GA, Betenbaugh MJ
Biotechnol. Bioeng., 2003;81(3):329-40.
Species: Hamster
Sample Type: Whole Cells
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| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
