| R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions. Extracorporeal photopheresis promotes IL-1beta production.
Authors: Yakut E, Jakobs C, Peric A, Michel G, Baal N, Bein G, Brune B, Hornung V, Hackstein H
J Immunol, 2015;194(6):2569-77.
Species: Human
Sample Type: Whole Cells
Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia.
Authors: Gonzalez-Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, Dube P, Bergman M, Orihuela C
PLoS Pathog, 2015;11(12):e1005337.
Species: Mouse
Sample Type: Whole Cells
Spleen Tyrosine Kinase (Syk) Mediates IL-1beta Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection.
Authors: Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J
J Biol Chem, 2015;290(28):17306-20.
Species: Human
Sample Type: Whole Cells
Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1beta Secretion: A Primary Human Monocyte Model.
Authors: Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, Dittmer D, Crowe J, de Silva A, Ting J
PLoS ONE, 2015;10(8):e0136708.
Species: Human
Sample Type: Whole Cells
The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity.
Authors: Li Q, Yokoshi M, Okada H, Kawahara Y
Nat Commun, 2015;6(0):6183.
Species: Human
Sample Type: Whole Cells
Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD.
Authors: Zwack E, Snyder A, Wynosky-Dolfi M, Ruthel G, Philip N, Marketon M, Francis M, Bliska J, Brodsky I
MBio, 2015;6(1):e02095-14.
Species: Mouse
Sample Type: Whole Cells
Application: Bioassay
CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages.
Authors: Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, Tsai I, Li L, Hsieh S
Blood, 2013;121(1):95-106.
Species: Human
Sample Type: whole cells
Application: Inhibitor
Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells.
Authors: McCloy R, Shelley E, Roberts C, Boslem E, Biden T, Nicholson R, Gee J, Sutherland R, Musgrove E, Burgess A, Butt A
Br J Cancer, 2013;109(12):3034-41.
Species: Human
Sample Type: whole cells
Application: cell culture
Increased sensitivity of early apoptotic cells to complement-mediated lysis.
Authors: Attali G, Gancz D, Fishelson Z
Eur. J. Immunol., 2004;34(11):3236-45.
Species: Human
Sample Type: Whole Cells
Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells.
Authors: Edgeworth JD, Spencer J, Phalipon A, Griffin GE, Sansonetti PJ
Eur. J. Immunol., 2002;32(5):1464-71.
Species: Human
Sample Type: Whole Cells
|
| 背景 | Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the initiation and execution of apoptosis. They are expressed as latent zymogens and are activated by an autoproteolytic mechanism or by processing by other proteases (frequently other caspases). Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). Caspases are regulated by a variety of stimili, including APAF1, CFLAR/FLIP, NOL3/ARC, and members of the inhibitor of apoptosis (IAP) family such as BIRC1/NAIP, BIRC2/cIAP-1, BIRC3/cIAP-2, BIRC4/XIAP, BIRC5/Survivin, and BIRC7/Livin. IAP activity is modulated by DIABLO/SMAC or PRSS25/HTRA2/Omi. Cell-permeable and irreversible peptide inhibitors are also available for different caspases. |
